Searchable abstracts of presentations at key conferences in endocrinology

ea0015p319 | Steroids | SFEBES2008

Sleep and cortisol profiles in healthy volunteers using an automated blood sampling machine

Phillips Suzanne , Henley David , Wilson Sue , Nutt David , Lightman Stafford

Sleep and cortisol cycles have a complex inter-relationship that is not fully understood. Slow wave sleep appears to have an inhibitory effect on cortisol production but the effect of other stages is not so clear. From diseases, such as Addisons disease and Cushings syndrome, we know that cortisol levels have an impact on the quality of sleep. In insomnia and depression, both sleep and cortisol is altered.To investigate this relationship properly a minim...

ea0012p70 | Neuroendocrinology and behaviour | SFE2006

Development of an automated blood sampling system for undisturbed blood sampling in humans

Taheri S , Henley D , Leendertz J , Russell G , Lightman S

IntroductionThe secretion of multiple hormones occurs in both a circadian and an ultradian manner. Both animal and human studies have shown that cortisol has an ultradian rhythm. Variations in ultradian cortisol secretion may explain inter-individual variation in the stress response.ObjectiveWe have developed an automated blood sampling system (ABS) that allows undisturbed sampling of blood, thus reducing str...

ea0011p876 | Thyroid | ECE2006

Comparison of TPOAb assays in early pregnancy

Henley R , Parkes AB , Taylor L , John R , Lazarus JH

The presence of thyroid peroxidase antibodies (TPOAb) is a marker of autoimmune thyroid disease and, when present in early pregnancy, is predictive of postpartum thyroiditis. In the course of undertaking the Controlled Antenatal Thyroid Screening Study we have taken the opportunity to measure TPOAb in a large number of samples from 11–16 weeks gestation by 3 different assays.The assays were (1) an in-house ELISA; (2) Bayer ADVIA Centaur anti-TPO ass...

ea0011p875 | Thyroid | ECE2006

Free thyroxine (FT4) is the analyte of choice in early gestation

Dando B , Taylor R , Henley R , Parkes AB , John R , Lazarus JH

Thyroid physiology in early pregnancy is characterised by an increase of thyroxine binding globulin. This has been taken into account when using total T4 (TT4) if a ‘T3 uptake test (TUp)’ is used to derive the FTI. The American Thyroid Association Guidelines (1990) recommend ceasing the use of uptake tests, although in the USA they are still widely used. The aim of this study is to compare the TT4 and TUp to the FT4 in early gestation. TT4, TUp, FT4 and TSH were meas...

ea0095oc9.1 | Oral Communications 9 | BSPED2023

Experience of the digital version of SEREN (Structured Education Reassuring Empowering Nurturing), Diabetes at Diagnosis module-improving paediatric diabetes care

D'Souza Nirupa , Pryce Rebekah , Davies Yvonne , Baker Claire , Townson Julia , Henley Josie

Background: SEREN is an established, QISMET accredited structured education programme for children/young people (CYP) and their families with Type 1 diabetes mellitus (T1DM), developed in Wales. The first module ‘Diabetes at diagnosis’ has been in use in Wales since 2016. The resources and health care professional (HCP) training have also been used by some paediatric diabetes teams in England who have since embedded SEREN into their diabetes care. Th...

ea0019p309 | Steroids | SFEBES2009

Corticosteroid-binding globulin (CBG) deficiency caused by a novel mutation in exon 3

Perogamvros I , Henley D , Hadfield K , Underhill C , Newman W , Hammond G , Lightman S , Ray D , Trainer P

Inherited CBG deficiencies are rarely reported and only 3 causative mutations in 4 families have been described. The objective of this study was to investigate a family with potential CBG deficiency.The index case, a 29-year-old female of Pakistani origin with consanguineous parents, presented with hirsutism and a slightly elevated 17-OHP. In a subsequent Short Synacthen Test (SST) 17-OHP was normal but serum cortisol (SerC) values were abnormal (case 1 ...

ea0081oc4.6 | Oral Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

ACROBAT advance: once daily, oral paltusotine treatment maintained long-term igf-1 at levels previously achieved with injectable long-acting somatostatin receptor ligands (LA-SRLs)

Gadelha Monica R , Randeva Harpal , Gordon Murray B , Mezosi Emese , Doknic Mirjana , Toth Miklos , Boguszewski Cesar L , Nichols Melissa , Jochelson Theresa , Henley Scott , Patel Meenal , Mendez Debbie Koh , Ferrara-Cook Christine , Krasner Alan , Casagrande Alessandra , Struthers R Scott

Paltusotine is a once-daily, oral, nonpeptide somatostatin receptor type 2 (SST2) specific agonist, in development for the treatment of acromegaly and neuroendocrine tumors. We report interim results from ACROBAT Advance (NCT04261712), an ongoing, multicenter, open-label, long-term extension study of paltusotine in subjects with acromegaly who previously completed either Phase 2 study ACROBAT Edge (NCT03789656) or Evolve (NCT03792555). ACROBAT Edge enrolled 47 subjects with el...

ea0041ep275 | Clinical case reports - Pituitary/Adrenal | ECE2016

A novel case of hypomagnesaemia secondary to fludrocortisone

O'Connor Henry , Proske Doerthe , Batool Asma , Shakher Jayadave

We present a case of fludrocortisone-induced hypomagnesaemia in a 27-year old female with Autoimmune Polyglandular Syndrome Type1, manifesting as adrenal insufficiency, hypothyroidism and hypoparathyroidism. Her medications were; Alfalcidol 4 mcg; Levothyroxine 100 mcg; Hydrocortisone 20 mg bid; Fludrocortisone 200 mcg mane and 100 mcg nocte. The nocturnal dose of fludrocortisone was started 4 months prior to her presentation. She presented with a history of abdominal pain and...

ea0031p324 | Steroids | SFEBES2013

Continuous measurement of free cortisol profiles

Bhake Ragini C , Leendertz Jack A , Linthorst Astrid C E , Lightman Stafford L

In order to understand the significance of circadian and ultradian hormonal rhythms in man, both in health and disease, it is essential to be able to obtain multiple samples over extended periods, especially during the hours of sleep. The human automated blood sampling (HABS) system reported by Henley and colleagues can achieve this but is recommended for use in the setting of a clinical investigation unit which is its major drawback. For many diagnostic and scientific questio...