Endocrine Abstracts

Background: Thyrotropin-secreting pituitary adenomas (TSH-omas) account for 1% of pituitary tumours. In addition to TSH, these tumours frequently secrete glycoprotein α-subunit (αSU) and up to 50% are immunoreactive for growth hormone (GH), although GH suppression following oral glucose tolerance testing (OGTT) has not been routinely performed in all patients to identify subclinical GH hypersecretion or abnormal GH suppression.Objectives: To ex...

Objectives: We have recently demonstrated a wide variation in insulin resistance (IR) occurs in polycystic ovarian syndrome and type 2 diabetes. Changes in insulin metabolism and increased insulin resistance (IR) after the menopause have previously been reported. It is unknown if the biological variation of IR is affected by the menopause and is evaluated here.Methods: The biological variation of IR was assessed by measuring IR at four day intervals on 10 consecutive occas...

Introduction and aims: Following treatment for acromegaly, both growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels are predictive of mortality. These data are derived from studies of either a single GH or the mean circadian GH, with a threshold of 2 mcg/l. However, consensus target criteria (Giustina et al. 2000) require: a nadir GH of <1 mcg/l on OGTT and IGF-I within the age/sex-adjusted normal range. We aimed to determine the degree to which norm...