Searchable abstracts of presentations at key conferences in endocrinology

ea0086d1.1 | Motion: This House believes that Vitamin D supplementation should be a high public health priority | SFEBES2022

This house believes that Vitamin D supplementation should be a high public health priority. For the motion

Hewison Martin

This year marks the 100th anniversary of vitamin D. Since its discovery in 1922 - as a factor that protects against the bone disease rickets - our understanding of vitamin D has evolved dramatically. Vitamin D has morphed from environmental/nutritional factor to steroid hormone endocrine regulator to intracrine modulator of transcription. Despite this, vitamin D-deficiency continues to be prevalent in the UK and nutritional rickets remains a significant clinical problem, notab...

ea0044s5.1 | New frontiers for Vitamin D | SFEBES2016

‘Free vitamin D’: another twist in the vitamin D story?

Hewison Martin

Research carried out over the last 10 years has supported a wider role for vitamin D in human health, with proposed beneficial effects for cancer, inflammation and infection and cardiovascular disease. A key component of this new perspective on vitamin D is the increased risk of common human diseases associated with decreased circulating levels of 25-hydroxyvitamin D (25D), more commonly referred to as vitamin D-deficiency. Although 25D is the major serum form of vitamin D, it...

ea0058s2.1 | Endocrine Track 1: Symposium 2 | BSPED2018

Vitamin D – beyond bone

Hewison Martin

The role of vitamin D in human health continues to attract much attention, both from academic research and the public media. This is due, in part, to continued concern about the prevalence of vitamin D-deficiency in countries such as the UK and the impact this may have on skeletal health, notably in children. However, in recent years vitamin D has also been linked to a wide range of extra-skeletal functions, suggesting that vitamin D-deficiency has a much broader impact on hum...

ea0022s14.3 | Novel actions of vitamin D | ECE2010

Vitamin D dependent anti-microbial pathways

Hewison Martin

Vitamin D is a pluripotent secosteroid whose actions extend far beyond classical effects on calcium homeostasis and bone metabolism. Vitamin D is known to exert powerful effects on both innate and adaptive immunity, with important consequences for both infectious and autoimmune diseases. Innate immune activities of vitamin D include the attenuation of antigen presentation by dendritic cells. However, recent attention has focused on the ability of vitamin D to stimulate antibac...

ea0021s5.2 | Vitamin D and calcium signalling in the immune system | SFEBES2009

Anti-bacterial action of vitamin D

Hewison Martin

Immunomodulatory properties of vitamin D have been recognized for more than 25 years. However, until recently it was unclear whether these actions of contributed to normal immune function. Two new developments have helped to clarify this. Firstly, our perspective on what constitutes normal vitamin D status has changed considerably, with the introduction of the term ‘vitamin D insufficiency’ to describe individuals with inadequate (but not rachitic) serum levels of 25...

ea0006s20 | The endocrinologist and bone | SFE2003

11beta-hydroxysteroid dehydrogenase type 1: a prereceptor regulator of glucocorticoids in bone

Hewison|M##Cooper|P##Stewart M

Glucocorticoids have potent but paradoxical effects on bone. In vitro they are required for the differentiation of osteoblasts but in excess can cause suppression of the mature osteoblast phenotype by reducing proliferation and inducing apoptosis. In vivo, glucocorticoids are anabolic at physiological concentrations, but in excess have an adverse effect on the skeleton most clearly seen in steroid-induced osteoporosis. We have postulated that this paradox may be ...

ea0050p043 | Bone and Calcium | SFEBES2017

Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

Li Danyang , Jeffery Louisa , Raza Karim , Hewison Martin

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

ea0050p043 | Bone and Calcium | SFEBES2017

Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

Li Danyang , Jeffery Louisa , Raza Karim , Hewison Martin

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

ea0065p347 | Reproductive Endocrinology and Biology | SFEBES2019

Vitamin D binding protein (DBP) is required for pro-invasion effects of vitamin D on placental trophoblastic cells

Ganguly Ankana , Shattock Alexandra , Joseph Annsha , Gupta Janesh , Hewison Martin

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) is abundant in decidua but its role in placental development is unclear. We hypothesized that decidual 1,25(OH)2D promotes placentation in early-pregnancy via actions on trophoblastic cell invasion. Using trophoblastic JEG3, BeWo and HTR8 cells we showed that 1,25(OH)2D has no effect on trophoblastic cell proliferation and migration in plasticware culture. However, in Matrigel t...

ea0044p45 | Bone and Calcium | SFEBES2016

Immunomodulation by vitamin D is associated with regulation of microRNAs

Li Danyang , Jeffery Louisa E. , Raza Karim , Hewison Martin

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), acting via the vitamin D receptor (VDR) is a potent regulator of gene expression, with effects on skeletal and extra-skeletal physiology. We have shown that actions of 1,25D on bone-forming osteoblasts also involve regulation of microRNAs (miRNAs) that play a key role in the functional development of these cells. In the current study, we have investigated miRNAs as mediators of innate and adaptive immune responses ...