Searchable abstracts of presentations at key conferences in endocrinology

ea0078oc4.4 | Oral Communications 4 | BSPED2021

Does Inflammation Underpin Polycystic Ovary Syndrome (PCOS)? A Proteomic Approach to Novel Non-Invasive Biomarker and Pathway Discovery in Adolescent PCOS

Gunn Harriet , Hallqvist Jenny , Doykov Ivan , Heywood Wendy , Steinbeck Katharine , Mills Kevin

Background and Methods: PCOS is common and associated with significant comorbidity. Yet, its pathogenesis is complex and poorly understood. We have developed new methods for deep phenotyping discovery proteomic profiling of urine to identify disease mechanisms and novel non-invasive biomarkers for PCOS in adolescents. We undertook proteomic analysis (nano 2D-LC-QTOF MSe) on a subset of 15 samples from a longitudinal PCOS cohort of 40 participants. We compared the ur...

ea0033oc4.6 | Oral Communications 4 | BSPED2013

Increased urinary megalin and cubulin excretion in children with type 1 diabetes mellitus: an association with low molecular weight protein loss

Sirka Ernestas , Manwaring Victoria , Peters Catherine , Amin Rakesh , Heywood Wendy , Hindmarsh Peter , Mills Kevin

Nephropathy remains a major diabetes related complication despite improvements in metabolic control. Current interventions are based on the appearance of albuminuria. Whether earlier detection and treatment might be beneficial is unclear. The reabsorption of low molecular weight (<70 kDa) plasma proteins in the renal proximal tubule is mediated by an endocytic receptor, megalin, and its coreceptor, cubulin.Using label free quantitative proteomics we ...

ea0029p997 | Growth hormone IGF axis - basic | ICEECE2012

Factors affecting IGF1 response to GH during transition

Thankamony A. , Capalbo D. , Heywood J. , Williams R. , Ong K. , Dunger D. , Simpson H.

Background: GH replacement during the childhood-adult transition period is important for somatic maturation. The aim of the study was to explore the factors influencing IGF1 response to GH during transition.Methods: KIMS (Pfizer International Metabolic Study) database in UK was interrogated, and 98 patients (55 male, median age 20.7 years (15.7–25.8)) with childhood-onset GH deficiency (Co-GHD), who were started on adult dose of GH during transition...

ea0028p250 | Pituitary | SFEBES2012

Factors affecting growth hormone (GH) replacement during transition in patients with childhood-onset GH deficiency

Thankamony Ajay , Capalbo Donatella , Rachel Williams , Heywood James , Ong Ken , Dunger David , Simpson Helen

Background: GH therapy during the transition period is important for somatic maturation. Identification of factors associated with low IGF-I levels may be useful in optimising GH replacement therapy.Objectives: To explore the prevalence and determinants of insufficient GH replacement during transitionMethods: Childhood-onset GH deficient (CO-GHD) patients (n=65) who stopped therapy, and were started on adult GH dose during t...

ea0024p37 | (1) | BSPED2010

Type 2 diabetes in childhood: building a platform for interventions to prevent the progression to cardiovascular disease

Barnett A , Barrett T , Cotter C , Dunger D , Fulton E , Heywood J , Ilsley E , O'Brien A , Shield J , Wales J

Type 2 diabetes (T2DM) is increasing in children in the UK and worldwide, most likely related to the rising prevalence of obesity. We are developing a UK national cohort of children (under 18 completed years) with diabetes defined by WHO criteria, suspected type 2, BMI above 85th centile; but who do not have genetically confirmed monogenic diabetes, secondary diabetes, or any evidence of pancreatic autoimmunity. The aim of this study is to describe the characteristics of the f...

ea0033oc3.2 | Oral Communications 3 | BSPED2013

GAD and IA2 autoantibody positivity is associated with a requirement for insulin treatment: results of the UK national paediatric Type 2 Diabetes cohort

Gray Zoe , Ilsley Emma , Cotter Catherine , Makusha Lydiah , Ford Anna , Turner Kelly , Heywood James , Chandler Kyla , Bingley Polly , Barnett Anthony , Dunger David , Shield Julian , Wales Jeremy , Barrett Timothy

Objectives: To establish the frequency of islet cell autoimmunity in children with a clinical diagnosis of type 2 diabetes (T2DM) and describe associated clinical and laboratory findings.Methods: We recruited children with: paediatrician diagnosis of T2DM; BMI above 85th centile for age and sex; children with other confirmed diagnoses such as monogenic and type 1 diabetes (T1DM) were excluded. Clinical data was collected into a national database. Blood w...

ea0030oc4.3 | Oral Communications 4 | BSPED2012

White UK children are older, more obese and more insulin resistant than non-White UK children at diagnosis of type 2 diabetes: baseline results of the UK national type 2 diabetes cohort

Gray Zoe , Ilsley Emma , Cotter Catherine , Makusha Lydiah , Ford Anna , Turner Kelly , Heywood James , Barnett Anthony , Dunger David , Hamilton-Shield Julian , Wales Jeremy , Barrett Timothy

Objectives: Type 2 diabetes (T2DM) has increased in UK children since the first reports in 2000; however it is poorly characterised and management practice varies across the UK. We aimed to describe the characteristics of the first 125 children recruited to the UK national study.Methods: We recruited children with: paediatrician diagnosis of T2DM; body mass index (BMI) above 85th centile for age and sex; other diagnoses such as monogenic diabetes exclude...

ea0027oc4.2 | Oral Communications 4 | BSPED2011

White UK children are older, more obese and more insulin resistant than non-White UK children at diagnosis of type 2 diabetes: baseline results of the UK national type 2 diabetes cohort

Barrett Timothy , Gray Zoe , Ilsley Emma , Cotter Catherine , Ford Anna , Turner Kelly , Heywood James , Barnett Anthony , Dunger David , Hamilton-Shield Julian , Wales Jeremy

Type 2 diabetes (T2DM) has increased in UK children since the first reports in 2000; however it is poorly characterised and management practice varies across the UK. We aimed to describe the characteristics of the first 103 children recruited to a national study. We wrote to paediatricians asking for children with: diagnosis of T2DM; body mass index (BMI) above 85th centile for age and sex; and other diagnoses such as monogenic diabetes excluded. Clinical data was collected in...

ea0033p30 | (1) | BSPED2013

GAD and IA2 autoantibody positivity is associated with a requirement for insulin treatment: results of the UK national paediatric type 2 diabetes cohort

Gray Zoe , Ilsley Emma , Cotter Catherine , Makusha Lydiah , Ford Anna , Turner Kelly , Heywood James , Chandler Kyla , Bingley Polly , Barnett Anthony , Dunger David , Hamilton-Shield Julian , Wales Jeremy , Barrett Timothy

Objectives: To establish the frequency of islet cell autoimmunity in children with a clinical diagnosis of type 2 diabetes (T2DM) and describe associated clinical and laboratory findings.Methods: We recruited children with paediatrician diagnosis of T2DM and body mass index (BMI) above 85th centile for age and sex. Patients with other confirmed diagnoses such as monogenic and type 1 diabetes (T1DM) were excluded. Clinical data was collected into a nation...