Searchable abstracts of presentations at key conferences in endocrinology

ea0015s35 | Evolving endocrine targets for C-type natriuretic peptide (CNP) | SFEBES2008

Novel cardiovascular roles for CNP

Villar C

C-type natriuretic peptide (CNP) represents a key paracrine member of the natriuretic peptide family that play an important role in the regulation of vascular tone and local blood flow. CNP is found abundantly in vascular endothelial cells and it is now clear that CNP can be released from the endothelium to act on adjacent cells, both in the vessel wall and the circulation. Thus, it has been shown that CNP hyperpolarises and dilates vascular smooth muscle in the mammalian resi...

ea0056gp122 | Endocrine Case Reports | ECE2018

A case of nivolumab induced fulminant type 1 diabetes

Frunza-Stefan Simona , Whitlatch Hillary

Introduction: Immunotherapy has revolutionized the treatment of cancer. Nivolumab, an anti-programmed cell death 1(PD-1) antibody, is used to treat several malignancies refractory to standard chemotherapy. While highly effective at prolonging patient survival, these agents can induce a wide range of endocrine immune-related adverse events (irAEs), including hypophysitis, thyroid dysfunction, and, uncommonly, type 1 diabetes (T1DM). Here we describe a rare case of PD-1 inhibito...

ea0022pl3 | Hypothalamic regulation of gonadotrophin secretion | ECE2010

Novel regulator of gonadotropin

Millar Robert

The central role of GnRH in gonadotropin was established over four decades ago. The development of agonist and antagonist analogs and the understanding of its interaction with the GnRH receptor has revolutionized the treatment of hormone-dependent diseases and controlled induction of ovulation for IVF.The absence of steroid and metabolic product receptors in GnRH neurons has presented a conundrum for understanding feedback and mechanisms for gonadotropin...

ea0094loe1.2 | Section | SFEBES2023

On the shoulders of giants: the gnrh sagas from discovery to new therapies

Millar Robert

The discovery of GnRH involved extraordinary insight, determination and creativity as well as conflict and competition where the players inadvertently advanced each other’s endeavours. However, many of us experienced great collegiality, collaboration and sharing reagents in these halcyon years. Many colourful and ambitious characters were involved in the recognition that a portal system transferred a factor from the brain to the pituitary supported by elegant experiments ...

ea0095oc7.4 | Oral Communications 7 | BSPED2023

T1D clinic- a novel approach!

Millar Sarinda , Magee Edel

In collaboration with local borough councils and the League of Diabetes and in response to severe staff shortages, the Southern Health & Social Care Trust (SHSCT), Northern Ireland, Type 1 Diabetes (T1D) team ran age banded group clinics at local Leisure centres. Due to unexpected and challenging staffing issues within the T1D team we had to think outside the box as to how we would deliver ‘clinic’ appointments in a timely manner to our children and young people ...

ea0063p738 | Pituitary and Neuroendocrinology 2 | ECE2019

Hemangiopericytoma mimicking a pituitary adenoma: a case report

Ernst Matthias E , Hiller Aimee , Reimann Regina , Serra Carlo , Schmid Christoph , Tschopp Oliver

Introduction: The differential diagnosis of sellar masses is broad and includes - apart from the most common pituitary adenomas - other neoplasms such as craniopharyngiomas, germinomas, gliomas, meningiomas, and others. Hemangiopericytoma (HPC) is a rare vascular tumor arising from pericytes that may appear at any site of the body. We report an unusual case of an intrasellar HPC.Case Report: A 63-year-old woman was admitted to our hospital complaining ab...

ea0029n7 | (1) | ICEECE2012

Neutralization of Flightless I (Flii) using Flii-specific monoclonal antibodies accelerates impaired healing in diabetic wounds through improved cell proliferation

Ruzehaji Nadira , Wallace Hillary , Stacey Michael , Fitridge Robert , Cowin Allison

Ulceration is a common and severe complication of diabetes affecting 15% of the 200 million patients with diabetes worldwide. A significant proportion of these chronic wounds fail to respond to conventional treatment, hence major amputation is a feared outcome of diabetes. More than 60% of non-traumatic amputations in the western world are performed in the diabetic population. There exists a growing need for effective therapeutic agents to improve healing in these wounds.<...

ea0021oc2.6 | Neuroendocrine tumours/pituitary | SFEBES2009

Laying the foundation for neuroendocrine control of human reproduction: an investigation into the development of kisspeptin and neurokinin B networks

Tello Javier , George Jyothis , Millar Mike , Anderson Richard , Millar Robert

The development and maturation of kisspeptin neurons is critical for activating GnRH release needed to initiate puberty. However, little is known of the development and organization of kisspeptin neurons in the human hypothalamus and the anatomical architecture of kisspeptin neurons in rodents is distinct from that of primates.The aim of the present study was to examine the development of the hypothalamic neuroendocrine circuitry that sets the structural...

ea0086p130 | Reproductive Endocrinology | SFEBES2022

Turner Syndrome - a case report illustrating the importance of early gynaecology input for women who are unable to tolerate progestins

Oo Win , Poole Ruth , Hillard Tim , Webster Daniel , Snape Sonya , Richardson Tristan , Page Georgina , Holt Helen

A 41-year-old woman with primary ovarian failure secondary to Turner syndrome presented in December 2020 with heavy vaginal bleeding. She had not attended appointments during the Covid-19 epidemic because of concerns around contracting the virus. She was anaemic with haemoglobin 47g/dl. Ultrasound showed grossly thickened and heterogenous endometrium (60 mm). Cross sectional imaging and hysteroscopy confirmed locally advanced endometrial carcinoma (Stage 3). She proceeded to h...

ea0016p380 | Neuroendocrinology | ECE2008

Pituitary insufficiency after traumatic brain injury and the coherence with psychological disorders

Wachter Dorothee , Guendling Katja , Oertel Matthias F , Stracke Hilmar , Boeker Dieter-Karsten

Objective: In order to explain physical, cognitive and psychological disorders after traumatic brain injury (TBI), several studies have implicated a major role of posttraumatic pituitary insufficiency (prevalence 25–70%). Aim of this study was to determine the correlation between cerebral tissue damage, corresponding initial findings on radiographic imaging and pituitary insufficiency versus psychological disorders (like fatigue, nervousness, depression or excitability).<...