Endocrine Abstracts

Introduction: Hoffman’s syndrome is a rare form of hypothyroid myopathy characterised with muscle hypertrophy, stiffness and wakefulness.Case report: A 43-years-old woman admitted to our hospital with a complaint of fatigue and progressive muscular weakness with cramps and myalgia started 3 months before.Thyroid gland examination was normal. On neurological examination she had proximal and lower limb muscle weakness(3/4) and hyporeflexia. Her calf m...

Background: Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudo-hypertrophy. Here, we report a case of Hoffman syndrome aggravated by statin therapy.Case report: We describe the case of a 60 year old woman with primary hypothyroidism who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelling of th...

Adult GH deficiency (AGHD) is a common sequela in patients with pituitary or brain tumors or in patients with a history of traumatic brain injury or cranial irradiation. In addition, approximately one third of children who were diagnosed with GH deficiency will remain GH deficient as adults. Since AGHD is characterized by diminished cardiovascular health, abnormal body composition, decreased muscle strength and aerobic capacity, poor quality of life, and increased mortality, i...

Background: Craniopharyngioma (CP) are the most common sellar tumors in children. Patients often develop excessive weight gain and obesity due to several factors as involvement or damage of the hypothalamus. Previous studies on the weight development in craniopharyngioma patients have shown an increase in weight before and in the first 10 years after diagnosis leading to an impaired quality of life. The long-term weight development in these patients has not been investigated t...

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)Hypothalamic involvement (HI) resulting in severe obesity is known to have major impact on quality of life in craniopharyngioma (CP) patients. HI is also associated with disturbances of satiety regulation leading to a failure to thrive and weight loss known as diencephalic syndrome (DS). The rate of DS and the outcome of CP patients with DS is unknown.Methods: CP patients h...

Objective: The main physiological function of the renin-angiotensin-aldosterone system (RAAS) is the regulation of water and salt homeostasis as well as arterial blood pressure. In addition, the RAAS is proposed to be involved in the pathophysiology of several diseases like hypertension, vascular remodelling, atherosclerosis, insulin resistance and type 2 diabetes mellitus. In a cohort study in north-east Germany, we investigated the association of plasma renin- (PRC) or plasm...

Background: Remote recurrence and metastasis are unusual complications in childhood-onset adamantinomatous craniopharyngioma mainly occurring either along a previous surgical route or by seeding via cerebrospinal fluid.Case description: An 11-year-old female patient initially presented with headache and neck pain as well as nausea over the course of 2 months. A sellar/suprasellar mass (4.0 cm×4.0 cm 5.0 cm) was detected on magnetic resonance imaging...

Objective: Hypothalamic obesity in childhood craniopharyngioma (CP) patients bares a high risk for development of metabolic syndrome. In metabolic syndrome, the development of nonalcoholic fatty liver disease (NAFLD) is known. The aim of this study is to detect the risk for NAFLD in childhood-onset CP.Design: This cross-sectional study included liver computed tomography (CT); ultrasound analysis of abdomen; measurements of serum parameters, height, weigh...

Objective: Pediatric patients with sellar masses such as craniopharyngioma (CP) or cyst of Rathke’s pouch (CRP) frequently suffer disease- and treatment-related sequelae. We analyzed the impact and prognostic relevance of initial hydrocephalus (HY) and hypothalamic involvement (HI) on long-term survival and functional capacity (FC) in children with CP or CRP.Subjects and methods: Using retrospective analysis of patient records, presence of initial H...

Objective: To determine the outcome of pregnancy in hypopituitary women.Background: Rare situation, not studied enough: only two previous studies concerning 9 and 19 patients (Overton et Hall).Design: Multicentric, descriptive, prospective and retrospective study.Material and methods: Twenty-one pregnancies were registered in 14 hypopituitary women (defined as gonadotropic deficiency associated with at least ...