Endocrine Abstracts

While carbamazepine (CBZ) treatment may affect serum thyroid hormone concentrations it rarely leads to clinically important hypothyroidism. This study was aimed to evaluate an early effect of CBZ on thyroid status in hypothyroid patients with thyroid hormone replacement, as compared with patients without a thyroid disorder.Twenty-nine patients indicated for CBZ treatment were followed prospectively. Their thyrotropin (TSH), total thyroxine (TT4) and free...

Paraneoplastic manifestations of well-differentiated thyroid carcinoma are not so common but they can be the first signal of cancer. We present a case of a man with Raynaud’s phenomenon in the area of the lower limb fingers. Clinical signs of Raynaud’s phenomenon with ulceration and gangrene of fingers of both lower limbs appeared several months before the diagnosis of papillary microcarcinoma of the thyroid was made. The diagnosis of carcinoma of the thyroid was det...

Introduction: Despite more than 60 years’ experience with radioactive iodine 131I (RAI) treatment of Graves’ disease (GD) about the most appropriate dosing regime is still controversial. The objective of our research was to analyse the outcome of RAI therapy in our cohort of patients.Methods: Retrospectively, we analysed 603 patients with GD (500 women and 103 men, mean age 51.5±12.7 years) treated with RAI. According to recomme...

Radioiodine (131I, RAI) has traditionally been used in thyroid cancer treatment but its benefitshould be balanced against possible risks. Among them, salivary gland dysfunction has oftenbeen discussed, although the reported data have been inconsistent. While some authors reported functional changes following higher (mostly cumulative) activities, there have been scarce data on the activity of 3.7 GBq (100 mCi) that is most commonly used for RAI remnant ablation...

Introduction: We tested our hypotheses that higher anxiety/depression scores can be connected with food preference of carbohydrates and higher insulin resistance.Methods: We examined 42 healthy men (average age 43.5±7.4 years, average BMI 27.4±5.7 kg/m2). Study protocol included filling in the self-asssessing scores of anxiety (SAS) resp. depression (SDS), carbohydrate-craving questionnaire (CCQ); assessment of 3-days diet records, h...

Background: Dopaminergic agonists have been proved to improve control of diabetes and lipids. Central dopaminergic activity can be measured by apomorphin test (apomorphin increases GH and decreases prolactin levels, which is a marker of dopaminergic activity).The aim of our study was to evaluate the relationship between central dopaminergic activity and metabolic parameters in healthy men.Methods: We examined 42 healthy men (averag...

Objective: Higher anxiety/depression scores can be connected with food preference of carbohydrates, with increased insulin secretion and thus can lead to insulin resistance. Three hypotheses were postulated: 1. more depressive (still in the normal range) subjects do not differ in the central serotoninergic activity from those less depressive. 2. the former do not differ in food preference and 3. in insulin resistance from the latter.Methods: healthy men,...

1500 euthyroid patients (1302 females and 198 males, mean age 47.8) presenting with thyroid enlargement were evaluated by fine needle aspiration (FNAC) of the thyroid as the first line investigation. The final cytological or histological diagnosis was determined after surgery (n=556) or clinical follow-up for a minimum period of 2 years (mean 9.5 yrs, range 2-19 years). Goitre type was assessed clinically and classified as diffuse in 184, multinodular in 457 or solitary nodule...

Pheochromocytoma is a rare neuroendocrine tumour usually formed in the adrenal medulla. Percutaneous biopsy has been associated with life-threatening haemorrhage, hypertensive crisis, capsular disruption with tumour implantation and death. We present a case of a 63 years old woman with non-specific clinical signs which included high blood pressure, headache, tachycardia and abdominal pain. She was treated for rheumatoid arthritis. Bilateral expansion of adrenal gland with dela...

Neuroendocrine tumours, especially pheochromocytomas, paragangliomas and pituitary adenomas, are more common in younger patients in 3rd–5th decade of life. PitNETs are the most common intracranial tumours, while PHEO and PGL are rare. The hormonal activity, signs and symptoms of NET are variable. PGL, PHEO and PitNET in one patient remains an exceptional association. 72 cases of concomitant pituitary adenoma and PGL have been reported to date. The first record of a patien...