Endocrine Abstracts

Peptidyl growth hormone secretagogues (GHS), including ghrelin and growth hormone releasing peptides (GHRPs), have been reported to exert cardioprotective effects in experimental models of ischemia-reperfusion (I/R) injury through GH-independent pathway. Along this line, we have identified CD36 as a main target for GHRP binding and action in the heart. Yet, not much is known regarding the molecular mechanisms of the cardioprotective effects of GHRPs. The objective of this stud...

It has long been known that the AR is regulated not only by its cognate steroid hormone, but also by interactions with a constellation of co-regulatory and signaling molecules. Checkpoint kinase 2 (CHK2) is a serine/threonine protein kinase whose main function is regulating the DNA damage response (DDR) triggered by double-strand DNA breaks. The androgen receptor (AR) is a major driver of prostate cancer, even at the castration–resistant stage of the disease. Our research...