Endocrine Abstracts

Hubert Vaudry, France-. AbstractDr Hubert Vaudry is Director of Research at the Institut National de la Santé et de la Recherche Médicale (INSERM), the French National Institute for Health, and Director of the Laboratory of Cellular and Molecular Neuroendocrinology at the University of Rouen. He was born in February 1946 in Le Havre, Normandy, and obtained his PhD at the University of Rouen in 1974. He then ...

The gut microbiota is now the subject of considerable investigation and our knowledge of its composition and understanding of functions are rapidly growing.Gut microbiota has profound impact on host physiology and it is now well-established that dysbiosis is associated with altered glycemic control and type 2 diabetes development. Targeting microbiota appears therefore as a promising strategy for the treatment of diabetic patients. Using probiotics in order to modulate blood g...

The renin angiotensin system (RAS) is well known for its role in the regulation of blood pressure and fluid homeostasis. Blockers of the RAS are widely used for the treatment of hypertension, cardiac failure and chronic renal insufficiency. Angiotensin I converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are usually quite well tolerated. In addition to the systemic effect of the RAS, evidence for an autocrine/paracrine role of this system has been w...

Spontaneous dizygotic (DZ) twinning results from a double ovulation and runs in families indicating a genetic component. Endocrinology studies in mothers of DZ twins observed higher levels of follicle stimulation hormone (FSH) and FSHB was, together with SMAD3, one the first loci identified as genome wide significant in genome-wide association studies (GWAS) of having DZ twins. Several additional loci were recently found that indicate genes involved with fema...

Introduction: Environmental pollutants especially those endowed with endocrine disrupting activities have been shown to contribute to metabolic related diseases suggesting that hormonal deficit conditions as observed in post-menopausal women may constitute aggravating conditions. To explore this hypothesis, we used the model developed in the laboratory which consists in a chronically exposure of mice to low-dosed chemicals in mixture incorporated in a high-fat-high-sucrose die...

Background: Pseudohypoaldosteronism type 1 (PHA1) is a primary form of mineralocorticoid resistance presenting in the newborn with renal salt wasting, failure to thrive and dehydration. Inactivating mutations of the NR3C2 gene, coding for the mineralocorticoid receptor (MR) are responsible for the vast majority of autosomal dominant and sporadic cases of renal PHA1. The underlying pathogenic mechanism involves both haploinsufficiency as well as a dominant negative mecha...

Objectives: Obesity is the major risk factor for the development of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). In addition, increased circulating levels of cytokines and chemokines and decreased adiponectin levels are associated with IGT and T2DM. However, a large part of morbidly obese patient remain normoglycemic. Therefore, we investigated if this protection can be attributed to a lower grade of inflammation or higher adiponectin levels.<p cla...

Introduction: Type 1 diabetes (T1D) and multiple sclerosis (MS) are autoimmune diseases with common immunological mechanisms. Type 1 diabetics have an increased risk of MS. The aim of this work is to report a clinical observation of a partial preservation of β-cell function in a type 1 diabetic patient treated early by Fingolimod for MS.Observation: A polyuro-polydipsic syndrome and a weight loss of 10 kg led to the diagnosis of T1D (typing HLA DR4/...

Pituitary gigantism is a rare condition caused by growth hormone secreting lesions, where treatment is usually challenging, especially in cases with genetic predisposition. Aim: We studied a gigantism cohort from Venezuela for genetic defects and their response to treatment. Subjects: 160 somatotropinoma patients were evaluated at the University hospital (from 1985–2015); eight (6M) were diagnosed with acrogigantism and underwent genetic analysis including aCGH for Xq26.3...

Background: The renin-angiotensin-aldosterone-system (RAAS) is a major regulator of blood pressure, however, there are no studies available addressing its characterization in a large clinical setting. Therefore, the aim of the present study was to describe the relationship between parameters of the RAAS and actual blood pressure results in a large cohort of patients with and without essential hypertension.Methods: We investigated 3253 patients (ages 63.2...