Searchable abstracts of presentations at key conferences in endocrinology

ea0035p12 | Adrenal cortex | ECE2014

New drugs switching off Wnt/β-catenin signaling in adrenocortical tumor cells

Rubin Beatrice , Pezzani Raffaele , Cicala Maria Verena , Iacobone Maurizio , Mantero Franco

Introduction: Adrenocortical tumors (ACT) are common diseases mostly benign, but among them, adrenocortical carcinomas (ACC) appear highly aggressive with metastatic potential. Wnt/β-catenin pathway is frequently switched on in ACT, with β-catenin greatly dephosphorylated and consequently activated. While IWR1 induces an increase in Axin2 protein levels, XAV939 inhibits tankyrase 1 and 2 (thus stabilizing Axin): both stimulate β-catenin phosphorylation and degra...

ea0032p20 | Adrenal cortex | ECE2013

Investigation of β-catenin, N-cadherin, and E-cadherin expression in adrenocortical tumors

Rubin Beatrice , Pezzani Raffaele , Cicala Maria Verena , Iacobone Maurizio , Olivotto Andrea , Fassina Ambrogio , Manteri Franco

Background: Adrenocortical tumors (ACT) are classified as adenomas (ACA) or carcinomas (ACC). β-Catenin constitutive activation is a frequent alteration in benign and malignant ACT. E-cadherin was discovered as a protein associated with β-catenin which plays a crucial role in cadherin-mediated cell adhesion. N-cadherin seems to be involved in the development of malignant ACT, but information regarding expression of N-cadherin or E-cadherin in ACT is very limited....

ea0029p40 | Adrenal cortex | ICEECE2012

The Wnt/Beta-catenin and Ras/Raf/MEK/ERK signaling pathways alterations in adrenocortical tumors

Rubin B. , Pezzani R. , Barollo S. , Mariniello B. , Salva M. , Iacobone M. , Fassina A. , Mantero F.

Adrenocortical tumors (ACT) include benign and malignant tumors. Adrenocortical carcinomas (ACC) are highly malignant neoplasms with a poor prognosis, but their genetic alterations to date identified are limited. Laboratory studies on ACT have revealed a wide variety of signaling pathways involved in these tumors, among these Wnt/β-catenin signaling pathway and Ras/Raf/MEK/ERK pathway resulted often disregulated. Another important factor in many signaling pathways is the ...

ea0020p8 | Adrenal | ECE2009

Effect of universal somatostatin analog (SOM230) on primary adrenal cell cultures

Mariniello Barbara , Finco Isabella , Rubin Beatrice , Patalano Anna , Ferasin Sergio , Iacobone Maurizio , Fassina Ambrogio , Mantero Franco

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

ea0016p19 | Adrenal | ECE2008

Angiogenic status of human adrenocortical tumors

Mariniello Barbara , Sartorato Paola , Finco Isabella , Patalano Anna , Iacobone Maurizio , Mantero Franco

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...

ea0081ep1019 | Thyroid | ECE2022

The hobnail variant of papillary thyroid carcinoma: clinical/molecular characteristics of a large monocentric series and comparison with conventional histotypes

Censi Simona , Manso Jacopo , Paganin Francesco , Vianello Federica , Galuppini Francesca , Pennelli Gianmaria , Iacobone Maurizio , Bertazza Loris , Barollo Susi , Mian Caterina

Background: Hobnail variant of papillary thyroid carcinoma (HPTC) has been recently identified. Given the rarity of the variant its characteristics have been studied only in little series, limiting the quality of the data available for its better management. The aims of our retrospective study were 1) to define the clinical and molecular characteristics of a series of HPTC in a monocentric and relatively large series; 2) to define the clinical and molecular characteristics abl...

ea0032p17 | Adrenal cortex | ECE2013

Role of adrenal vein sampling in primary aldosteronism: impact of different diagnostic criteria on subtype diagnosis

Cicala Maria-Verena , Salva Monica , Miotto Diego , Rubin Beatrice , Pezzani Raffaele , Patalano Anna , Iacobone Maurizio , Mariniello Barbara , Mantero Franco

In patients with primary aldosteronism (PA), adrenal vein sampling (AVS) is considered the gold standard to distinguish between unilateral and bilateral autonomous production of aldosterone, while diagnostic imaging tests by CT scan or MRI are often inconclusive for the diagnosis. To date agreement is lacking on the best criteria indicating successful cannulation and lateralization.The aim of the study was to evaluate the impact of different diagnostic c...

ea0035p536 | Endocrine tumours and neoplasia | ECE2014

Aurora kinases inhibitors Vx-680, SNS314 and ZM447439 in adrenocortical tumors

Pezzani Raffaele , Rubin Beatrice , Bertazza Loris , Cicala Maria Verena , Barollo Susi , Iacobone Maurizio , Mian Caterina , Scaroni Carla , Ulisse Salvatore , Mantero Franco

Background: Adrenocortical tumors (ACT) include benign and malignant forms. Adrenocortical carcinomas (ACC) are highly malignant neoplasms with poor prognosis and strong metastatic potential. Aurora kinase family members (AK) are serine/threonine kinase involved in the regulation of mitosis. Aurora kinase A (AKA) promotes centrosome maturation and spindle assembly, while aurora kinase B (AKB) is necessary for spindle assembly checkpoint and cytokinesis.A...

ea0011p528 | Endocrine tumours and neoplasia | ECE2006

Characterization of familial non-syndromic pheochromocytoma

Opocher G , Schiavi F , Iacobone M , Sattarova S , Erlic Z , Martella M , Mian C , Zambonin L , De Lazzari P , Murgia A , Favia G , Mantero F

Hereditable forms account for 30–40% of pheochromocytomas (pheo). The role of germ-line mutation of VHL, RET, SDHB, SDHD gene has been largely elucidated. However, genotyping a group of 172 sporadic or familial pheo, we have characterize five unrelated probands with familial pheo without any sequence variants of RET (7 exons), or of the entire coding sequence of VHL, SDHB, SDHC or SDHD.The proband #1 had a bilateral pheo when 32 and a local recurren...

ea0081rc6.6 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

The clinical and molecular evaluation of the GIP/GIPR axis in Medullary Thyroid Cancer (MTC)

Occhi Gianluca , Bertazza Loris , Barollo Susi , Galletta Eva , Mondin Alberto , Zovato Stefania , Iacobone Maurizio , Zilio Eleonora , Avallone Serena , Lefkimmiatis Konstantions , Di Benedetto Giulietta , Mian Caterina , Scaroni Carla , Regazzo Daniela

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a 7-transmembrane class B G-protein coupled receptor that mediates the incretin response after nutrient stimulation. Although mostly involved in metabolic disorders, in the last years an improper activation of the GIP/GIPR axis has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. In Medullary Thyroid Cancer (MTC), a neuroendocrine tumor of the parafollicular C...