Searchable abstracts of presentations at key conferences in endocrinology

ea0015p98 | Clinical practice/governance and case reports | SFEBES2008

Biochemical diagnosis of sporadic phaeochromocytoma: an audit of 24 h urinary catecholamine excretion (UCAT) requests from primary and secondary care

Leelarathna Lalantha , Owen Lisa , Bailey Stephanie , Bainbridge Hannah , Iversen Andrew , Crown Anna

Objectives: The audit was carried out to inform the development of a local protocol for investigation of patients with suspected sporadic phaeochromocytoma.Method: Details of all UCAT tests performed in 2006 for a catchment area of approximately 500 000 were obtained.Questionnaires were used to obtain further information about all the patients referred from primary care and secondary care patients with UCAT > upper limit of nor...

ea0014p91 | (1) | ECE2007

Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients, who display fat redistribution

Haugaard Steen B , Andersen Ove , Halsall Ian , Iversen Johan , Nicholas Hales Charles , Madsbad Sten

Beta-cell function of HIV-infected patients on highly active antiretroviral therapy (HAART), who display lipodystrophy, may be impaired. An early defect in beta-cell function may be characterized by an increased secretion of 32–33 split proinsulin (SP) and intact proinsulin (IP).To address this issue the secretion pattern of SP and IP of 16 HIV-infected men with lipodystrophy (LIPO) and 15 HIV-infected men without lipodystrophy (NONLIPO) were studie...

ea0011p244 | Cytokines and growth factors | ECE2006

CD4 T-cell count improves during sustained IGF-I response following low dose growth hormone therapy in HIV-infected patients on stable antiretroviral regimens. A pilot study

Andersen O , Hansen BR , Flyvbjerg A , Madsbad S , Ørskov H , Nielsen JO , Iversen J , Haugaard SB

Objective: High dose growth hormone (rhGH) regimens (2 to 4 mg/day) have been shown to increase circulating insulin-like growth factor (IGF)-I to supra-physiological levels in human immunodeficiency virus (HIV)-infected patients on combined antiretroviral therapy (CART). This setting may improve immunologic output. However, a high plasma IGF-I concentration has detrimental effects on glucose metabolism, which hampers the use of high dose rhGH regimens.Me...

ea0011p819 | Thyroid | ECE2006

Bioavailability of iodine bound in humic substances in drinking water and the impact on thyroid function

Andersen S , Gustenhoff P , Iversen F , Terpling S , Pedersen KM , Laurberg P

Both humic substances (HS) and iodine may influence the thyroid gland. Tap water is a major source of iodine intake in some areas, where iodine has been shown to be bound in HS.We investigated tap water and old subjects from two areas with and without iodine bound in HS in tap water, to assess their importance for urinary iodine excretion and for the thyroid. Analysis of tap water, measurement of iodine in urine and thyrotropin (TSH), thyroid peroxidase ...

ea0031pl7biog | Clinical Endocrinology Trust Lecture | SFEBES2013

Clinical Endocrinology Trust Lecture

Lightman Stafford

Stafford Lightman is Professor of Medicine at the University of Bristol and is Director of the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology. He started his scientific career working on catecholamines and opioid peptides with Leslie Iversen at the University of Cambridge and provided some of the first data linking opioid peptides with the regulation of neurohypophysial function. At this time he also performed some of the first studies demonstrating...