Searchable abstracts of presentations at key conferences in endocrinology

ea0021se1.6 | (1) | SFEBES2009

Animated enchantment: an investigation of the enduring popularity of Walt Disney's first feature films

Jacobs Howard

In this talk, which will include part my submission for a PhD in Film Studies in the University of London, I explore some of the reasons for the widespread and enduring popularity of Disney’s first feature-length animated films (Snow White and The Seven Dwarfs (1937), Pinocchio (1940), Dumbo (1941) and Bambi (1942)). Despite their old fashioned style, the first two have recently been rereleased – in 70th anniversary editions in Blu-Ray for...

ea0005s39 | HRT - The Good, the Bad and the Ugly | BES2003

HRT and fracture prevention

Jacobs H

With the recent publication of the results of randomised controlled trials (RCTs) of HRT we are at last developing the potential to assess the relative safety as well as the relative efficacy of preventative treatment. As detailed on the website of the Medicines Control Agency (www.mca.gov.uk), treatment with HRT is associated with an increased risk of cancer of the breast and ovary, of stroke and venous thromboembolism, together with an increased rate of surgery for gallstone...

ea0007p195 | Reproduction | BES2004

Analysis of hCG beta core fragment glycosylation in normal and aberrant pregnancy by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry

Malatos S , Jacoby E , Juneja N , Butler S , Kicman A , Iles R

Metabolism of the dimeric glycoprotein hormone human chorionic gonadotrophin (hCG) results in the urinary excretion of hCG beta core fragment originating from the beta subunit of hCG (hCGbeta). hCG beta core fragmant retains a certain antigenic shape as well as two metabolically processed N-linked oligosaccharides. Hyperglycosylation of hCGbeta has been used as an indication of aberrant pregnancy especially in malignant disease. We have previously characterised the carbohydrat...

ea0016p585 | Paediatric endocrinology | ECE2008

Autosomal dominant hypophosphatemic rickets (ADHR) due to a novel mutation in the FGF23 gene

Clausmeyer Susanne , Jacobi Christoph , Haffner Karsten , Pohl Martin , Schulze Egbert , Raue Friedhelm

Two dominant inherited disorders of phosphate homeostasis, X-linked hypophosphatemia (XLH), and ADHR are known to be caused by inactivating mutations in the PHEX gene or activating mutations in the FGF23 gene (fibroblast growth factor 23), respectively. Both diseases show a similar phenotype with renal phosphate wasting and inappropriately normal or low 1,25-(OH)2-Vitamin D3 serum levels, leading to hypophosphatemic rickets and osteomalacia. The different...

ea0090p31 | Calcium and Bone | ECE2023

Bone mineral density in children and adolescents with Cystic Fibrosis

Tamer Gizem , Gerardus Maria Arets Hubertus , Kors van der Ent Cornelis , Margo van Santen Hanneke , Jacoba van der Kamp Hetty

Background: Bone health can be affected in (young) adults with Cystic Fibrosis (CF) due to different risk factors in childhood. We aimed to analyze the prevalence of low bone mineral density (BMD) during childhood in patients with CF, its risk factors and course in time.Methods: A longitudinal prospective cohort study was performed in children with CF aged 8-18. Anthropometric, DEXA scans and endocrine data were collected. BMD z-scores were adjusted for ...

ea0077oc3.2 | Metabolism, Obesity and Diabetes | SFEBES2021

Comparing the transcriptional landscape between lean and obese mice within the small intestinal segments

Jacobs Margot , West Jason , Rajagopalan Harith , Bewick Gavin

Background: Obesity is a complex metabolic disease characterised by excess adipose tissue, that increases the risk of comorbidities such as type II diabetes. Interventions that rearrange the gut architecture or exclude nutrients from the duodenum promote immediate and long-term anti-diabetic effects, placing the gut front and centre in obesity and diabetes pathology and treatment. Currently, little is known about the pathological changes which occur in the small intestine (SI)...

ea0050ep030 | Bone and Calcium | SFEBES2017

Hypercalcaemic crisis secondary to a large cystic parathyroid adenoma

Jacobs Alana , Wijetilleka Sajini , Sharma Aditi , Muralidhara Koteshwara

We report the case of an 82-year-old lady who was admitted with hypercalaemic crisis (adjusted Calcium 4.82 mmol/L) and acute kidney injury (creatinine 169 micromol/L). PTH was 295 pmol/L, raising the suspicion of an underlying parathyroid carcinoma. She had no palpable neck mass. Her ALP was 131 IU/L and Vitamin D 73 nmol/L; myeloma screen was negative and chest radiograph showed no pathology. A DEXA scan revealed osteoporosis. The hypercalcaemic crisis...

ea0050ep030 | Bone and Calcium | SFEBES2017

Hypercalcaemic crisis secondary to a large cystic parathyroid adenoma

Jacobs Alana , Wijetilleka Sajini , Sharma Aditi , Muralidhara Koteshwara

We report the case of an 82-year-old lady who was admitted with hypercalaemic crisis (adjusted Calcium 4.82 mmol/L) and acute kidney injury (creatinine 169 micromol/L). PTH was 295 pmol/L, raising the suspicion of an underlying parathyroid carcinoma. She had no palpable neck mass. Her ALP was 131 IU/L and Vitamin D 73 nmol/L; myeloma screen was negative and chest radiograph showed no pathology. A DEXA scan revealed osteoporosis. The hypercalcaemic crisis...

ea0057029 | Rara avisor recurrence of papillary thyroid carcinoma | BES2018

Rara avis or recurrence of papillary thyroid carcinoma

Elias De Meyst , Bert Bravenboer , Daniel Jacobs-Tulleneers-Thevissen

A 21-year-old woman underwent total thyroidectomy and unilateral central neck dissection for papillary thyroid carcinoma. Four of the removed lymph nodes tested positive for metastasis. Additional radioactive iodine treatment was given and the post I-131 therapy total body scan showed increased uptake of iodine-131 in a thyroid remnant but none in any of the lymph nodes. Postoperatively thyroglobulin levels decreased but remained elevated. During follow-up, a nodular enlargeme...

ea0041ep255 | Clinical case reports - Pituitary/Adrenal | ECE2016

Iatrogenic cushing syndrome and acute adrenal insufficiency due to the association of inhaled corticosteroids and ritonavir

Zubillaga Ivana , Frances Carla , Nicolau Joana , Sanchis Pilar , Blanco Jacobo , Conchillo Concepcion , Masmiquel Lluis

Introduction: Hepatic metabolism of inhaled corticosteroids (ICS) takes place via cytochrome P450 3A4. Nevertheless, it can be decreased by enzyme inhibitors such as itraconazole or ritonavir, thus leading to an increase in the bioavailability of ICS. This can result in an accumulation of the steroid drug and a cushing’s syndrome.Case report: We present the case of a 48 year old woman with human immunodeficiency virus (HIV) infection on highly activ...