Searchable abstracts of presentations at key conferences in endocrinology

ea0034p323 | Reproduction | SFEBES2014

Interaction of androgen with IGF signalling in preantral follicle development in the mouse ovary

Jamall Hina , Laird Mhairi , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age. It is characterised by excessive ovarian androgen production which, in turn, has been implicated in the aetiology of aberrant follicular development. We have previously reported that prenatal exposure to androgens activates follicle growth1. It has been suggested that androgens may interact with the IGFs to promote the activation and growth of follicles. The aim of thi...

ea0032p465 | Diabetes | ECE2013

Vitamin B12 deficiency in type 2 diabetic patients on metformin

Niafar Mitra , Jamali Behrad , Alikhah Hosseyn , Bahrami Amir

Introduction: Metformin is the only biguanide that is currently in use as an oral hypoglycemic agent in type 2 diabetes mellitus (DM). There are reports about the vitamin B12 deficiency in metformin users. This study was aimed to evaluate the vitamin B12 deficiency in patients with type 2 DM using metformin or other hypoglycemic agents.Methods: A descriptive-comparative study was performed on 400 patients with type 2 DM presenting t...

ea0084op-08-37 | Oral Session 8: Basic 2 | ETA2022

Resistance to thyroid hormone alpha: molecular, biochemical and physiological approach to diagnosis and therapy

Agostini Maura , Pietzner Maik , Marelli Federica , Prapa Matina , Moran Carla , Edward Visser W. , Brown Dave , Thomas Ellen , Schoenmakers Erik , Romartinez-Alonso Beatriz , Scheuplein Rabea , Tylki-Szymanska Anna , Lyons Greta , Watson Laura , Rajanayagam Odelia , Schwedhelm Edzard , F. Hartmann Michaela , Wudy Stefan , Probst Maiken , MacDonald Stephen , Thomas William , Arlt Wiebke , Volker Uwe , M. Main Katharina , Feldt-Rasmussen Ulla , T. Dattani Mehul , Koren Dahll Louise , Demir Korcan , Kara Cengiz , Kirbiyik Ozgur , Mammadova Jamala , Cayır Atilla , Yarali Oguzhan , Phan-Hug Franziska , Sakremath Rajesh , Mohamed Zainaba , Shinawi Marwan , Gill Harpreet , pacaud Daniele , Perrier Renee , Poke Gemma , Hunter Wendy , Douzgou Sofia , Wakeling Emma , Gardham Alice , Lim Derek , Shears Deborah , Freel Marie , Omladic Jasna , Tansek Mojca , Writzl Karin , Farooqi Sadaf , Kopp Peter , Schwabe John , Persani Luca , Chatterjee Krishna

Objectives: THRA mutations cause Resistance to Thyroid Hormone α (RTHα), an underdiagnosed disorder with hypothyroid features but near-normal thyroid function tests (TFTs). We developed a pathway, combining molecular analyses, new biomarkers and physiological measurements, to better diagnose and treat this disorder.Methods: Structural and functional analyses of THRA variants, discovered by next generation sequencing in specifi...