Searchable abstracts of presentations at key conferences in endocrinology

ea0011p846 | Thyroid | ECE2006

Similarities in the role of FoxE1 in thyrocytes and keratinocytes?

Bullock M , Jehani M , Bowden P , Ludgate M

Patients with non-functional FOXE1 (forkhead transcription factor) display congenital hypothyroidism, ‘spikey’ hair and other abnormalities. In the thyroid, FoxE1 controls migration of the developing gland and adult expression of thyroid specific genes. Our earlier studies demonstrated FOXE1 protein expression in keratinocytes of the epidermis and hair-follicle outer root sheath.We aimed to characterise the expression and functional activity of...