Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep148 | Calcium and Bone | ECE2023

Efficacy and safety of Cinacalcet therapy for patients with primary hyperparathyroidism: A retrospective observational study

Johnsen Hakon , Kalhan Atul

Introduction: Cinacalcet therapy remains the only alternative to elective parathyroidectomy (EP) for lowering serum calcium (Ca) in patients with primary hyperparathyroidism (PHPT). National Institute of health and Care Excellence (NICE), UK support use of cinacalcet in symptomatic patients with PHPT who decline surgery (or deemed unfit for surgery), if serum Ca levels >2.85 mmol/l. The limitation in wider use of cinacalcet remains cost effectiveness apart from limited dat...

ea0020oc1.5 | Endocrine Tumours | ECE2009

Bone morphogenetic protein 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

Johnsen Inga , Kappler Roland , Auernhammer Christoph , Beuschlein Felix

Bone morphogenetic proteins (BMPs) have been demonstrated to impact tumorigenesis in a variety of tumors. As for the adrenal cortex, quantitative real time PCR analyses revealed down-regulation of various BMPs (e.g. BMP2, BMP5) in tissue samples from adrenocortical carcinoma and adrenocortical tumor cell lines in comparison to normal adrenal glands. Other members, by contrast, as seen for BMP6 remained unaltered. Integrity of BMP dependent pathways in the investigated cell lin...

ea0016oc4.3 | Bone and adrenal | ECE2008

BMP dependent modulation of adrenocortical growth and function

Johnsen Inga K , Spady Lilia , Shapiro Igor , Beuschlein Felix

Bone morphogenic proteins (BMPs) have been demonstrated to impact tumorigenesis in a variety of tumors. As for the adrenal cortex, BMP6 has been implicated as an important modulator of aldosterone secretion. To screen for alterations of BMP dependent pathways in adrenal tumorigenesis we performed gene profiling experiments. By comparing human adrenal carcinoma (ACC) against normal adrenal glands (Co) we detected a down-regulation of various BMPs (e.g. BMP2, BMP5) which was fur...

ea0014oc3.3 | Endocrine tumors & neoplasia | ECE2007

BMP dependent effects on adrenal tumorigenesis and function

Johnsen Inga , Kaufmann Sarah , Spady Lilia , Beuschlein Felix

Members of the TGFb family of ligands - including bone morphogenic proteins (BMPs) - have been demonstrated to profoundly impact tumorigenesis in a variety of tumor entities. As for the adrenal cortex, BMP6 has been implicated as an important modulator of aldosterone secretion. To screen for alterations of TGFß dependent pathways in adrenal tumorigenesis we performed gene profiling experiments. By comparing human adrenal carcinoma (ACC) against normal adrenal tissue sampl...

ea0081ep775 | Pituitary and Neuroendocrinology | ECE2022

Distribution of E- and N-cadherin in subgroups of non-functioning pituitary neuroendocrine tumours

Astrid Berland Oystese Kristin , Casar-Borota Olivera , Berg-Johnsen Jon , Berg Jens Petter , Bollerslev Jens

Purpose: Clinically Non-Functioning Pituitary Neuroendocrine Tumours (NF-PitNETs) present a varying degree of aggressiveness, and reliable prognostic markers are lacking. We aimed to characterize the distribution of E- and N-cadherin in corticotroph, PIT1 and null-cell NF-PitNETs, and link it to the clinical course of the tumours.Methods: We investigated the distribution of E- and N-cadherin by immunohistochemistry in a retrospective cohort of thirty tum...

ea0090p427 | Pituitary and Neuroendocrinology | ECE2023

Long-term Surgical Remission in Patients with Acromegaly in South-Eastern Norway

Maria Falch Camilla , Kirstine Dupont Anne , Olarescu Cristina , Bollerslev Jens , Berg-Johnsen Jon , Heck Ansgar

Context: Immediate and sustained cure of acromegaly can only be achieved by surgery, however, most growth hormone (GH) producing adenomas are macroadenomas (≥ 10 mm) at diagnosis, with reported surgical cure rates of approximately 50% compared to microadenomas (<10 mm) with an expected higher cure rate (around 80%). Further, long-term data on remission rates after surgery are sparse. Aim: Estimate short- and long-term surgical remission rates o...

ea0011p489 | Endocrine tumours and neoplasia | ECE2006

Evaluation of a standardized protocol for the collection and storage of adrenal tumor samples – preparation for an European adrenal tumor bank (ENS@T)

Johnsen I , Hahner S , Fassnacht M , Bertherat J , Bertagna X , Plouin PF , Reincke M , Allolio B , Beuschlein F

Tissue samples from adrenal tumors provide the basis for standard diagnostic procedures such as pathological examination. In addition, these tumor samples have been an invaluable source for the discovery of novel molecular pathways involved in adrenal tumorigenesis. Information on the molecular phenotype are based on DNA mutation analysis and epigenetic changes, RNA and protein expression pattern and sub-cellular localization as well as post transcriptional protein modificatio...