Endocrine Abstracts

Introduction: An undefined lesion detected by imaging methods in one or both adrenals is known as an incidentaloma. The size and capacity of the secretion are evaluated to determine its definitive management. It is extremely uncommon for a mixed adrenal incidentaloma to appear with elevated cortisol and medullar hormone output.Case report: A 21-year-old woman was admitted to the hospital with intermittent palpitations, headaches, and chest pain. She was ...

The diagnosis of adult growth hormone deficiency (GHD) in patients with pituitary disease relies predominantly on provocative tests of GH secretion. The incidence of GHD in treated acromegalic patients has not been fully documented. Therefore, the aim of the present study was to elucidate GH response to insulin-induced hypoglycaemia (ITT, 0.15 IU/kg i.v.) in a cohort of 10 patients with acromegly considered cured solely by transsphenoidal surgery (6 females and 4 males, mean a...

Criteria to define biochemical remission of acromegaly following surgery have changed over the years, but still the controversy about current consensus exists. We assessed seventy newly diagnosed patients with acromegaly (43 females and 27 males, mean age 46.9±1.4 years, range 17–66 yrs) 8 weeks after transsphenoidal pituitary adenomectomy done by the same neursurgeon. Current consensus criteria were used to define postoperative remission: glucose-suppressed (nadir) ...

Posttreatment assessment of the disease activity and definition of cure of acromegaly, by measuring GH secretion, remains problematic. Furthermore, with our efforts to achieve tight biochemical control of the disease it is foreseeable that a proportion of patients may be rendered GH deficient (GHD). The aim of our study was to evaluate residual GH secretion in cured patients with acromegaly. The study was approved by the Hospital Ethical Committee and after informed consent, b...

Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became ...

IntroductionHyponatremia is frequently encountered in clinical practice. Euvolemic hyponatremia (Syndrome of Inadequate Antidiuresis, SIAD) represents diagnostic and management challenge regarding etiology unraveling, its gradual acute substitution, and later causal treatment.Case reportA 68-year-old woman was admitted to the Emergency unit with acute psychosis. On examination, there were no focal neurologica...