Endocrine Abstracts

Polymyalgia rheumatica is a chronic autoimmune inflammatory rheumatic disorder of unknown aetiology. Hashimoto thyroiditis is an autoimmune thyroid disorder characterised by the presence of antithyroid antibodies. Hashimoto thyroiditis has been described in patients with systemic autoimmune disorders such as systemic lupus erythematosus. The aim of the study was to describe the case of a patient who had polymyalgia rheumatica and developed Hashimoto thyroiditis.<p class="a...

Introduction: Extended Forsteo® Observational Study (ExFOS), a multinational, non-interventional, prospective, observational study, designed to evaluate fractures, back pain (BP), adherence and health-related quality of life (QoL) in teriparatide (TPTD) treated patients, based on the extension of treatment duration (24 months) and the addition of new indications (glucocorticoid-induced and male osteoporosis) was compared with EFOS.Methods...

Objective: The clinical phenotype of PCOS includes reproductive and hormonal aberrations. Visceral adiposity index (VAI) is an indicator which could connect hyperandrogenism and anovulation. The objective was to evaluate the relationship between VAI, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with PCOS.Patients: 180 women with PCOS diagnosed with Rotterdam criteria.Measurements: We correlated V...

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...

Background: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder and hyperandrogenism and insulin resistance constitute the key players of syndrome pathogenesis. Another emerging important factor of PCOS is low-grade chronic inflammation. The aim of the present study was to investigate white blood cells count (WBC) in PCOS and assess its role as a possible marker of low-grade inflammation.Methods: Anthropometrical, metabolic and hormonal data...

Objective: To investigate the effects of oral natural micronized progesterone on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question if induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in PCOS subjects.Design: Prospective clinical study.Setting: Academic medical centre.Population: Twenty eight ...