Searchable abstracts of presentations at key conferences in endocrinology

ea0035s3.3 | News from thyroid hormones: central transport, energy control and oxidative stress | ECE2014

Oxidative damage to macromolecules in the thyroid gland: experimental evidence

Karbownik-Lewinska Malgorzata

Oxidative processes are of special significance in the thyroid gland, as they are indispensable for thyroid hormone synthesis. It is estimated that huge amount of reactive oxygen species, especially of hydrogen peroxide (H2O2), are formed in the thyroid under physiological conditions. Also iron, present in thyroperoxidase, is required for thyroid hormone synthesis. Both, H2O2 and iron, constitute substrates of the most basic reaction...

ea0020s26.2 | Thyroid, Pregnancy and Fertility | ECE2009

Thyroid dysfunction during pregnancy

Karbownik-Lewinska Malgorzata

Thyroid physiology demonstrates certain specificity during pregnancy. Due to the increased thyroid hormone formation, observed in the course of gestation, the requirements for dietary iodine increase substantially – according to the current recommendations – to 250 μg/day (but <500 μg/day). Therefore, additional iodine supplementation is advised at the level of 150 μg/day to be administered to every pregnant (and lactating) woman. Thyroid hyperstim...

ea0007p244 | Thyroid | BES2004

The expression of mRNA for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase) in the tissue of papillary thyroid carcinoma (PTC) and of medullary thyroid carcinoma (MTC) in humans

Karbownik M , Brzezianska E , Lewinski A

Thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase) are the enzymes involved in pyrimidine and purine metabolism; TK1 activity is correlated with growth processes, and dThdPase is involved in the mechanisms of angiogenesis. The increased activities of TK1, dCK and dThdPase or the increased expression of genes for theses enzymes have been found in different tumors. The aim of the study was to estimate the expression of mRNA, specific for...

ea0016p295 | Endocrine tumours | ECE2008

Melatonin restores the basal level of lipid peroxidation in rat tissues under conditions of exposure to potassium bromate

Stasiak Magdalena , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Potassium bromate (KBrO3) is a known prooxidant and carcinogen. Melatonin is a highly effective antioxidant. Indole-3-propionic acid (IPA) – an indole substance, and propylothiouracil (PTU) – an antithyroid drug, also reveal some antioxidative effects. The aim of the study was to evaluate KBrO3-induced lipid peroxidation in vitro in tissues collected from either control or melatonin-treated rats, and to compare potential preventive effect...

ea0011p799 | Thyroid | ECE2006

Increased lipid peroxidation in critically ill patients with low-T3 syndrome

Karbownik M , Kokoszko A , Jozefiak M , Lewinski A

Low-T3 syndrome (euthyroid sick syndrome) develops in critically ill patients. Due to the catabolic state, accompanying critical illnesses, enhanced oxidative damage to macromolecules is expected to occur in subjects suffering from the low-T3 syndrome.The study aimed at evaluating the level of lipid peroxidation products in blood serum, collected from critically ill patients with the low-T3 syndrome and at estimating the ...

ea0049ep1325 | Thyroid (non-cancer) | ECE2017

The manner of performing the thyroid ultrasound examination and the reliability of assessment of the thyroid size in school-aged children

Zygmunt Arkadiusz , Adamczewski Zbigniew , Karbownik-Lewinska Malgorzata , Lewinski Andrzej

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

ea0032p1075 | Thyroid (non-cancer) | ECE2013

Protective antioxidative effects of caffeic acid phenethyl ester in the thyroid and the liver are similar to those caused by melatonin

Kokoszko-Bilska Agnieszka , Stepniak Jan , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Whereas oxidative reactions occur in all tissues and organs, the thyroid gland constitutes such an organ, in which oxidative processes are indispensable for physiological functions. Thus, with additional oxidative abuse caused by several factors, increased oxidative damage to macromolecules may occur in the thyroid. In turn, numerous metabolic reactions occurring in the liver create favourable conditions for huge oxidative stress.Melatonin is a well-know...

ea0029p1565 | Thyroid (non-cancer) | ICEECE2012

Potassium iodide, but not potassium iodate, as a potential protective agent against oxidative damage to membrane lipids in porcine thyroid

Milczarek M. , Stepniak J. , Lewinski A. , Karbownik-Lewinska M.

Introduction: Fenton reaction (Fe2++H2O2 →Fe3++ ′OH+OH−) is of special significance in the thyroid gland, as both its substrates, i.e. H2O2 and Fe2+, are required for thyroid hormone synthesis. Also iodine, an essential element supplied by the diet, is indispensable for thyroid hormone synthesis. It is well known that iodine affects red-ox balance. One of the most frequent...

ea0020p75 | Thyroid | ECE2009

Influence of thiamazole, lithium carbonate or prednisone administration on the efficacy of radioiodine treatment (131I) in hyperthyroid patients

Oszukowska Lidia , Knapska-Kucharska Malgorzata , Karbownik-Lewinska Malgorzata , Lewinski Andrzej

Introduction: Effects of selected drugs on the efficacy of (131I) radioiodine therapy were examined.Material and methods: The study involved 200 hyperthyroid patients, treated with radioactive iodine. They were divided into five (5) groups (40 persons in each). In group I – beside 131I, patients were additionally administered antithyroid drugs, in group II – 131I and lithium carbonate, group III – 131<...

ea0020p114 | Thyroid | ECE2009

Analysis of demographic and clinical factors, affecting the outcome of radioiodine therapy in patients with hyperthyroidism

Kanpska-Kucharska Malgorzata , Oszukowska Lidia , Karbownik-Lewinska Malgorzata , Lewinski Andrzej

Introduction: The influence of demographic and clinical factors on the outcome of 131I therapy in hyperthyroid patients has been examined, based on a retrospective evaluation of results obtained in patients, submitted to 131I treatment. The goal of the study was an analysis of factors, including the age and sex of patients, disease duration time, as well the hormonal status before 131I application, which could have influenced the effects of the...