Endocrine Abstracts

Adiponectin is a soluble protein produced solely by matured adipocytes. Adipogenesis contributes to the pathogenesis of GO in many ways including a direct effect on proptosis due to increased volume of mature adipocytes.The aim of the study was to estimate an influence of immunosupresive and anti-inflammatory treatment using systemic corticotherapy combined with orbital radiotherapy on serum adiponectin level in GO patients. The study was accepted by Eth...

The aim of the study was to compare efficacy and tolerability of systemic corticotherapy alone to corticotherapy combined with orbital radiotherapy in severe active Graves’ ophthalmopathy. We studied 905 patients, aged 35–73 years (mean 58.2 ±12), with clinical activity score above 4 and ATA class 3c to 6. Therapeutic outcome was assessed by change in ophthalmopathy index. For 4 weeks all subjects received corticotherapy: 869 - oral prednisone 60–100 mg dai...