Endocrine Abstracts

Drug-induced Hyperprolactinaemia is commonly observed and frequently poses diagnostic and managerial difficulties. Clearly, it is important to ensure that there is no underlying pathological cause, such as a hypothalamic or pituitary tumour, which would need addressing separately. Anti-psychotic medications are a common cause of this condition, although this is not observed in some newer atypical antipsychotics. Other common causes include anti-depressants, anti-hypertensives,...

Introduction: Hyponatraemia is the most common electrolyte disturbance, affecting 15–20% of emergency admissions to hospital. It is associated with increased mortality and length of stay in hospital. This audit was performed to evaluate how well hyponatraemia is being investigated and managed in the Acute Assessment Unit (AAU).Methods: Sodium level on admission for all patients attending AAU at Conquest Hospital over a 1-...

Introduction: Hyponatraemia is the most common electrolyte disturbance, affecting 15–20% of emergency admissions to hospital. It is associated with increased mortality and length of stay in hospital. This audit was performed to evaluate how well hyponatraemia is being investigated and managed in the Acute Assessment Unit (AAU).Methods: Sodium level on admission for all patients attending AAU at Conquest Hospital over a 1-...

Introduction: We describe a case of young girl, who initially presented with androgen producing adrenal adenoma, and post-operatively, the other adrenal gland profoundly cortisol suppressed, raising suspicion, if it was originally co-producing both androgen and cortisol.Case report: A 29-year-old girl initially presented, with 8 months history of hirsutism and cranial hair loss.She had a normal menarche and menstrual cycles and con...

Introduction: We describe a case of young girl, who initially presented with androgen producing adrenal adenoma, and post-operatively, the other adrenal gland profoundly cortisol suppressed, raising suspicion, if it was originally co-producing both androgen and cortisol.Case report: A 29-year-old girl initially presented, with 8 months history of hirsutism and cranial hair loss.She had a normal menarche and menstrual cycles and con...

In 1976, aged twenty, Mr A J was diagnosed with a cerebral haemangioblastoma, which was successfully removed. His father died from renal cell carcinoma and a Pheochromocytoma, raising the possibility of VHL syndrome. Genetic screening was positive but no follow-up was provided.In 2004, aged 48, he presented with a two year history of persistent diarrhoea. A CT scan revealed a left sided 1.7 cm adrenal adenoma. Serial 24 h urine metadrenaline ranged betwe...

68 Y M Has Background of Hypertension and Asthma. Presented with progressive visual deterioration for 12 months in 2012. VF testing confirmed Bitemporal Hemianopia. He has symptoms suggestive of cortisol excess. Therefore, MRI pituitary and pituitary hormone profile was done. MRI showed pituitary macroadenoma A Pituitary Hormone profile in 2012 showed cortisol excess at value of 755 nmol/l and ACTH 156 ng/l(0–46). IGF-1 17.2 nmol/l which is normal. LDDST was done and cortisol ...

Background: The plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenoma. Mixed Growth hormone and prolactin secreting adenomas are the commonest one, approximately 5% of surgically removed adenoma. Other hormonal mixture of adenoma may occur, but very rare. We present a rare case of co-secreting TSH and GH adenoma. Clinical Case: A 45 year old gentleman, generally fit and well, presented with 3 years history of blurred visi...

Section 1: Case History: A 45-year-old gentleman attended the emergency department in December 2016 with an episode of stupor, confusion and lethargy with blood glucose of 1.8 mmol/l. He recovered after administration of IV glucose. He had ’funny spells’ for a year prior to the event. He had a history of childhood asthma and was not on any regular medications. There were no significant findings in the clinical examination and no relevant family history. <p class=...

Introduction: Diabetes mellitus (DM) is a common co-morbidity in patients with heart failure and reduced left ventricular ejection fraction (HF-REF), and is associated with adverse prognosis. Subgroup analyses of randomized controlled trials suggest patients with DM benefit prognostically from beta-adrenoreceptor blockers (BB) and angiotensin converting enzyme inhibitors (ACEi). However, it remains unclear whether escalating doses of these age...