Endocrine Abstracts

We present the case of a girl with rapidly progressing central precocious puberty, CPP. The young girl presented with consonant rapidly progressive puberty and onset of menarche. She had onset of breast budding at 7 years 11months, menarche at 8 years 2 months, with significant growth spurt. Periods continued every 3 weeks. A Brain MRI demonstrated a dysplastic lesion of her tectal plate. She underwent treatment with Gonadotropin releasing hormone analogues to suppress puberty...

Maturity-onset diabetes of young 5 (MODY5) is a type of monogenic diabetes involving multiple organs including pancreas and kidneys. This is caused by mutation/deletion of the hepatocyte nuclear factor-1β (HNF-1β) gene located in the chromosome region 17q12.We report a 10-year-old, non-obese girl who was diagnosed with diabetes with features of insulin resistance. She was found to have a heterozygous whole gene deletion of HNF-1&#9...

Introduction: One third of children in the UK are overweight or obese. The Obesity Services for Children and Adolescents (OSCA) group have agreed upon a guideline for paediatricians on the assessment and management of obese children.Audit aim: To evaluate and improve the care of obese and overweight children.Method: Obese patients seen in secondary care were retrospectively audited from 2008 to 2014.Results: ...

Objectives: The use of CSII in very young diabetic children was initially limited. The criteria for continued use are better long term glycaemic control and reduced hypoglycaemia episodes. The objective of this study was to evaluate the benefits of CSII on glycaemic control, acute complications and quality of life of diabetic patients.Methods: Retrospective analyses of data from patients with type 1 diabetes from our database that were started on CSII fr...

Radioidine (RI) has been implicated as an adverse factor causing deterioration of Thyroid-Associated Ophthalmopathy (TAO). Oral steroids administered after RI appear to protect patients' eyes, and this practice is now widespread. Two factors may confound the controversy surrounding the effects of RI on TAO. Firstly hypothyroidism, which is common after RI and is independently detrimental to the eyes, and secondly studying patients who are in different phases of the natural his...

Background: The anti-hyperglycemic effects of thiazolidinedione/biguanide combination therapy are well established. However, the impact of such therapy on other clinical risk factors for cardiovascular disease (CVD) has not been extensively reported.Objective: To evaluate the anti-hyperlipidemic effects of pioglitazone (PIO) and rosiglitazone (ROSI) used in combination with metformin (MET) in patients with type 2 diabetes, a multicenter, retrospective, r...

Background: The anti-hyperglycemic effects of thiazolidinedione/biguanide combination therapy are well established. However, the impact of such therapy on other clinical risk factors for cardiovascular disease (CVD) has not been extensively reported.Objective: To evaluate the anti-hyperlipidemic effects of pioglitazone (PIO) and rosiglitazone (ROSI) used in combination with metformin (MET) in patients with type 2 diabetes, a multicenter, retrospective, r...

Background: Obese young people are likely to suffer significant morbidity in adult life. Successful intervention during adolescence may have far-reaching benefits. Evidence is emerging that patient-responsive clinical services may deliver improved outcomes.Aims: To assess the perceptions of obese young people about weight and weight-management services.Method: Annonymised, postal questionnaire survey of 116 obese young people (9&#1...

Surgical management for parathyroid disease worldwide is on the rise. Hand in hand, parathyroid surgery has evolved from the classical bilateral approach to the more focussed unilateral approach. The failure rate in the best of hands continues to be 3–4% but this figure may rise as Minimally Invasive Surgical techniques are universally adopted.Accurate pathological diagnosis to differentiate parathyroid adenomas from hyperplasia continues to be diff...

INTRODUCTION: Hyperprolactinaemia frequently causes secondary hypogonadism through central suppression of gonadotropin secretion. Macroprolactinomas (>1cm diameter) may additionally cause more generalised hypopituitarism; a recent series finding the prevalence of TSH and ACTH deficiencies to be 35% and 9%, respectively. Recovery of the thyrotropic and/or corticotropic axes is well described following surgery to pituitary tumours, but remains poorly defined in relation to me...