Searchable abstracts of presentations at key conferences in endocrinology

ea0039ep39 | Diabetes | BSPED2015

Young people with type 1 diabetes of non-white ethnicity and lower socioeconomic status have poorer glycaemic control in England and Wales – a national population-based study

Khanolkar Amal R , Amin Rakesh , Taylor-Robinson David , Viner Russell M , Warner Justin T , Stepenhson Terence

Introduction: The impact of ethnicity and socioeconomic status (SES) on glycaemic control in children with type 1 diabetes (T1D) is poorly understood in England and Wales.Methods: We studied 18 478 children and young people with T1D aged <19 years attending diabetes clinics in England and Wales and included in the 2012–2013 National Paediatric Diabetes Audit (NPDA). Self-identified ethnicity was categorized as white, Asian, black, mixed, other a...

ea0015oc21 | Tumours, diabetes, bone | SFEBES2008

Delineating the mechanisms of Visfatin regulation in human AT and the implications of TZD treatment in Type 2 Diabetes

McGee Kirsty , Harte Alison , da Silva Nancy , Creely Steven , Baker Adam , Kusminski Christine , Khanolkar Manish , Evans Marc , Chittari Madhu , Patel Vinod , Boardman Shirine , Kumar Sudhesh , McTernan Philip

Objective: The adipocytokine visfatin, expressed in abdominal adipose tissue (AT) is thought to mimic insulin activity. However, whilst central adiposity is closely related to insulin resistance (IR) and T2DM, visfatinsÂ’ role in the development of these conditions remains unclear.Method: We investigated circulating visfatin levels in non-diabetic (ND) and diabetic (T2DM) subjects and in T2DM patients pre- and post- rosiglitazone (RSG) treatment. We ...

ea0011p398 | Diabetes, metabolism and cardiovascular | ECE2006

The in vitro and in vivo role of diabetic status and insulin sensitisers on the novel adipocytokine, visfatin

McGee KC , da Silva NF , Baker AR , Harte AL , Creely SJ , Hill MJ , Khanolkar M , Evans M , Kumar S , McTernan PG

Visfatin, a novel adipocytokine preferentially expressed in omental (Om) adipose tissue (AT), has been shown to exert insulin-mimetic effects in mice and humans. Recent studies in Asian populations show elevated serum visfatin levels in subjects with Type 2 Diabetes Mellitus (T2DM), suggesting a potential role for visfatin in the pathogenesis of this disease. Whilst central adiposity is closely related to IR and T2DM, the role of AT in the development of these conditions remai...