Searchable abstracts of presentations at key conferences in endocrinology

ea0011oc11 | Steroids and reproductive endocrinology | ECE2006

The adrenal X-zone is involved in progesterone inactivation

Beuschlein F , Heshkovitz L , Klammer S , Lichtenauer U , Shapiro I , Krup M , Weinstein Y

20alpha-hydroxysteroid dehydrogenase (20αHSD) has been initially characterized as a progesterone metabolizing enzyme of the ovary mandatory for the final reduction of progesterone blood levels before parturition. As the exact zonal distribution and regulation of adrenal 20αHSD has not been defined, adrenal 20αHSD expression and activity was determined by western blotting, immunohistochemistry and enzymatic assays in wild type BALB/c mice of both genders at diffe...

ea0011p429 | Endocrine disruptors | ECE2006

The UV filter benzophenone 2 inactivates human recombinant thyroperoxidase in vitro and disturbs thyroid hormone homeostasis in rats

Schmutzler C , Bacinski A , Ambrugger P , Klammer H , Wuttke W , Grüters A , Jarry H , Köhrle J

UV filters are produced in high amounts for multiple uses. Their main application is in sun lotions for skin protection against accelerated ageing or cancer, but they are also found in many other cosmetics or in plastic materials to prevent their radiation-induced damage. Regardless of these protective properties, UV filters seem to interfere with both the reproductive and the thyroid endocrine axis. We here screened for effects of the UV filter benzophenone 2 (BP2) on thyroid...

ea0029p499 | Diabetes | ICEECE2012

Selective suppression of slow wave sleep does not affect insulin sensitivity in patients with type 1 diabetes

Donga E. , van Dijk M. , Lammers G. , van Kralingen K. , van Dijk G. , Corssmit E. , Romijn J.

Background: Human sleep is composed of different sleep stages, of which slow wave sleep (SWS) is an important modulator of glucose regulation. Curtailment of sleep duration in general and of slow wave sleep (SWS) in particular reduces glucose tolerance in healthy subjects. Previously, we have reported that a single night of partial sleep deprivation reduces insulin sensitivity by 15–20% in patients with type 1 diabetes. We hypothesized that this effect could be a conseque...

ea0026p718 | Diabetes (epidemiology, pathophysiology) | ECE2011

Disturbed subjective sleep characteristics in adult patients with type 1 diabetes mellitus

van Dijk M , Donga E , van Dijk J G , Lammers G J , van Kralingen K W , Dekkers O M , Corssmit E P M , Romijn J A

Introduction: Sleep restriction and/or impaired sleep quality negatively influence glucoregulation. The aim of this study was to assess subjective sleep parameters in patients with type 1 diabetes, to relate sleep parameters to long-term glycaemic control, and to assess possible risk factors for impaired sleep.Research design and methods: We studied 99 adult patients with type 1 diabetes (55M, 44F, duration of diabetes 26.9±1.2 years) and 99 age-, g...

ea0026p294 | Pituitary | ECE2011

Patients previously treated for nonfunctioning pituitary macroadenomas have disturbed sleep characteristics, circadian movement rhythm, and subjective sleep quality

Joustra S D , Biermasz N R , Donga E , Pereira A M , Van Duinen N , Van Dijk M , Van der Klaauw A A , Corssmit E P M , Lammers Gert Jan , Van Kralingen Klass , Van Dijk J G , Romijn J A

Context and objective: Fatigue and excessive sleepiness have been reported after treatment of nonfunctioning pituitary macroadenomas (NFMA). Because these complaints may be caused by disturbed nocturnal sleep, we evaluated objective sleep characteristics in patients treated for NFMA.Design: Controlled cross-sectional study.Subjects and methods: We studied 17 patients (8 women, mean age 54 years), in remission of NFMA during long-te...