Endocrine Abstracts

Introduction: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare disease inherited in an autosomal dominant pattern, caused by mutations in the MEN1 gene. The cardinal components of this syndrome are: primary hyperparathyroidism (PHPT), gastroenteropancreatic neuroendocrine tumors (NETs) and pituitary tumors.Aim: The aim of the study was to evaluate clinical features of MEN1 patients under care of two teritiary centers in Warsaw, Poland with special fo...

Introduction: Thyroid diseases are frequent in acromegalic patients. We aimed to investigate thyroid function and morphology in a population of patients with de novo acromegaly.Materials and methods: We evaluated 32 patients newly diagnosed with acromegaly in a single medical center. We collected data on patient’s age, sex, duration of acromegaly symptoms, history of thyroid disease, laboratory tests results (serum GH, IGF1, TSH, fT4, fT3, ...

Background: The curative therapy of primary hyperparathyroidism (pHPT) is surgery. Data about ultrasound-guided laser ablation (LA) of parathyroid tumor are limited, however it could be a solution for patients with high surgery or anesthetic risk. We report our experience on LA of parathyroid tumors in 11 patients with pHPT with high surgery or anesthetic risk.Methods: LA was performed under ultrasound guidance with an output power of 3W. Total energy an...

Background: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare, autosomal dominant disease characterized by the coexistence of at least two of the following: primary hyperparathyroidism (PHPT), neuroendocrine tumors (NET) and pituitary tumors. The aim of the study was to evaluate epidemiology, clinical features and management of MEN1 patients in two referral centers in Warsaw, Poland.Material and Methods: Study group consisted of 52 patients, aged from...

Introduction: Secondary hyperthyroidism due to thyrotropin-secreting pituitary adenoma (TSHoma) is rare. Coexistence of TSHoma and primary thyroid disease that could lead to hyperthyroidism is even more unusual.Case report: A 28-year-old female with longstanding and worsening symptoms of hyperthyroidism was admitted to the hospital. Free-T4 (32.89 pmol/l) and free-T3 (6.38 pg/ml) were elevated with moderately increased TSH level (5....

Introduction: Ultrasound imagining of parathyroid lesions is often challenging, as they may be difficult to distinguish from thyroid lesions or enlarged lymph nodes.Aim: The aim of the study was to assess the value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates-(FNA) in preoperative localization of parathyroid lesions.Materials and methods: We measured FNA–PTH in 30 consecutive patients with pr...

Introduction: Data regarding the thyroid gland evaluation in Polish adolescents are limited.Aim: The aim of the study was to asses TSH and anti-thyroid peroxidase antibodies (anti-TPO) concentrations as well as thyroid morphology on ultrasound in Warsaw adolescents in regard of family history of thyroid disease.Materials and methods: The study was carried out on a group of 480 adolescents (285 girls and 195 boys), aged 17–18 y...

Introduction: Real-time elastography (RTE) is a noninvasive ultrasound method of estimation of tissue stiffness by measuring the degree of local tissue displacements after a small compression. Recent data has shown indicate on its ability to differentiate benign and malignant tumors. The aim of the study was to evaluate the diagnostic accuracy of RTE in the diagnosis of malignant and benign thyroid nodules.Material and methods: A total of 75 thyroid nodu...

The aim of the study was to evaluate factors determining bone mineral density (BMD) and serum concentrations of osteocalcin (OC) and carboxyterminal telopeptide of type I collagen (ICTP) in acromegaly. Material consisted of 121 patients with active acromegaly, aged 23–80 years. In the whole group BMD, assessed by DXA, was: 0.35±0.15 at L2–L4, 0.60±0.11 at femoral neck, 0.05±0.12 at Ward’s triangle and 0.59±0.13 at trocha...

Introduction: 24-hydroxylase, encoded by a CYP24A1 gene, is a crucial enzyme entailed in catabolism of vitamin D. Loss-of-function mutations of CYP24A1 result in hypercalcemia, not adequately concomitant high levels of 1,25(OH)2D and low PTH levels. The variety of clinical manifestations depends on age – mutations can lead to fatal infantile hypercalcemia among neonates (typically precipitated by supplementation of vitamin D), whereas adults’ symptoms are usually mil...