Searchable abstracts of presentations at key conferences in endocrinology

ea0011p675 | Reproduction | ECE2006

Evidence for synergy of SHBG and androgen receptor genes in PCOS phenotype

Xita N , Georgiou I , Psofaki V , Kolios G , Tsatsoulis A

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with hyperandrogenemia to be its strongest genetically determined characteristic. Our aim was to investigate the potential synergy of two functional polymorphisms: the (TAAAA)n polymorphism of the sex hormone-binding globulin gene (SHBG) known to be associated with PCOS and influence serum SHBG levels (longer repeats were associated with lower SHBG levels) and the (CAG)n polymorphism of androgen receptor gene (...

ea0032oc5.2 | Reproduction | ECE2013

The (TAAAA)n polymorphism in the SHBG gene is related to prenatal androgenization of female fetus: possible implications of the developmental origin of metabolic disorders

Pamporaki Christina , Xita Nectaria , Lazaros Leandros , Makridimas George , Georgiou Ioannis , kolios George , Plachouras Nikolaos , Tsatsoulis Agathocles

Introduction: The aim of this study was to examine whether the distribution of SHBG (TAAAA)n repeat variants contributes to the exposure of the female fetus to androgen excess, by influencing the, in utero, androgen availability.Methods: The study population consisted of 100 pregnant women that carried female fetuses and underwent the procedure of amniocentesis due to age (older than 35). Blood samples and amniotic fluid samples were dr...

ea0016p640 | Reproduction | ECE2008

The role of sex hormone-binding globulin (SHBG) and aromatase (CYP19) gene variants in the development of polycystic ovary syndrome (PCOS)

Xita Nectaria , Lazaros Leandros , Georgiou Ioannis , Psofaki Vasiliki , Kolios George , Tsatsoulis Agathocles

Background of study: Experimental research supports the hypothesis that fetal exposure to androgen excess may programme in utero the development of PCOS in adult life. Potential mechanisms for prenatal androgenization could be a reduced binding capacity of androgens by SHBG or reduced aromatization of androgens by aromatase. The aim of this study was to examine whether the SHBG(TAAAA)n polymorphism, known to be associated with SHBG levels and the CYP19(TTTA)n<...