Endocrine Abstracts

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

Corticotropin-releasing hormone (CRH) and Urocortin 2 (Urn2) are secreted locally in peripheral tissues and play a direct immunomodulatory role as endocrine or paracrine mediators of inflammation. Studies on CRH as well as Ucn2 and vascular endothelial cells suggest that CRH may play a pivotal role in the regulation of vascular endothelial function under normal and pathological conditions. The present study was undertaken to determine whether CRH and Urn2 affect the endothelia...

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) not only functions as a central glycolytic enzyme but also is implicated in the process of apoptosis and gene transcription moving between the cytosol and nucleus. Oxidative stress modifies the activity of GAPDH.The aim of the study was to determine whether oxidative stress (OS) in diabetics is associated with induction of the apoptotic process and higher GAPDH translocation to the nucleus in PBMCs.<p ...

Introduction: There is indirect evidence of unfavorable effects of parathyroid hormone (PTH) on glucose metabolism. Teriparatide (recombinant human PTH 1-34 - TPTD) has been recently available for the treatment of osteoporosis.Aim: To evaluate the acute and chronic effect of TPTD on blood glucose and insulin levels in women with established osteoporosis.Patients and methods: Twenty-three postmenopausal women with established osteop...

Introduction: Hyperglycemia in type 1 diabetes mellitus (T1DM) is an important determinant of bone health. However, data on the effect of glycemic changes on bone metabolism are limited. The aim of this study was to evaluate BMD in patients with T1DM in relation to changes of glycemic control.Methods/Design: We studied 118 uncomplicated patients with T1DM (GroupD) (mean age: 30.12+8.78years, F/M: 65/53) and 94 healthy controls (GroupC) matched for age, s...

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), pho...

Introduction: Type 2 diabetes mellitus (T2DM) affects bone metabolism, but its relation with bone mineral density (BMD) remains controversial. It is also known that T2DM is associated with hypogonadism in males. Male hypogonadism can also affect BMD. Thus the aim of this study was to evaluate BMD in male patients with T2DM with and without hypogonadism.Methods/design: Hypogonadism was defined as serum free Testosterone (fT) value <5 ng/dl or 5–9...

Aim: To measure Urocortin3 (Ucn3) blood levels in morbidly obese (MO) non diabetic patients before and after laparoscopic sleeve gastrectomy (LSG) for excess body weight reduction and explore its relationship with b-cell function. Ucn3 is involved in insulin secretion in the presence of nutrient excess, a key feature of obesity, and may be an integral part of the compensation of β-cells function.Methods: Nine MO patients who underwent LSG and 11 hea...

Introduction: GH deficiency in adulthood is associated with increased cardiovascular risk, which is attributed to unfavorable changes in body composition and in metabolic parameters.Aim: We evaluated haemodynamic, metabolic, inflammatory and coagulation indices that may contribute to the increased cardiovascular risk in GH deficient subjects.Methods: Twenty-four patients diagnosed with GH deficiency (13 male), with a mean (S...