Endocrine Abstracts

Given the importance of transcriptional regulation in metabolic control, we investigated the role of nuclear receptor co-factors in the liver, a key organ in energy homeostasis. Here we show in mice that the expression of receptor interacting protein 140 (RIP140) in the liver is induced in catabolic states like fasting and cancer cachexia. In contrast, chronic high fat diet feeding reduced RIP140 mRNA levels in the liver. Increased hepatic RIP140 in catabolic conditions was as...