Endocrine Abstracts

GIP-dependent Cushing’s syndrome (CS) is caused by ectopic expression in adrenal cortex of gastric inhibitory peptide (GIP) receptors coupled to steroidogenesis, which leads to postprandial increases of cortisol (food-dependent CS). In a few cases a transient effect of short-acting octreotide on cortisol levels has been shown, but bilateral adrenalectomy is still thought to be a definitive treatment.We report on a case of a 45-year old woman with bi...

Multidimensional studies of medical aspects of ageing were performed in 6 provinces of Poland, the protocol included cross sectional analysis of thyroid function parameters.The sample was randomly chosen and included 4,051 respondents (49.2% females).Group consisted of 3,502 elderly subjects aged 65–90+y, divided into approximately equal six age subgroups; and 549 younger cohort, aged 55–59 y.Thyroi...

Obesity is considered as a state of chronic, systemic low-grade inflammation. Likely causes include infectious factors, leptin, cigarette smoking, low serum HDL-cholesterol and high serum triglycerides. No definitive confirmation on the causative factor is available so far.The aim of the study was to evaluate serum levels of C-reactive protein (hs-CRP, sensitivity 0,085 ng/L), IL-6, IL-10, TNF-α and its soluble type 2 receptor (sTNF-αR-2) in vi...

In the 1980s the concept, that some individuals with normal weight (Metabolically Obese, Normal-Weight) have disturbances of metabolism, related to obesity was proposed. It is known, that obesity promotes atheromatosis by various mechanism, inter alia due to excess of inflammatory markers. This problem however, was not investigated in non-obese subjects.We analyzed anthropometric variables, body fat distribution by DXA and serum CRP, Il-6 and Il-18 in 43...

Pleiotropic effects of vit. D in the etiology of obesity, metabolic syndrome and diabetes are still debated. So far published reports considered only changes in vit D plasma level in individuals with obesity and diabetes, and did not take into account the role of polymorphisms in the vit. D receptor gene.The aim of the study was to evaluate obesity, carbohydrate and lipid metabolism and vitamin D level in two VDR polymorphisms (Fok and Bsm) in Polish agi...

The levels of bone turnover markers are elevated e.g. in osteoporosis, neoplastic diseases with bone involvement (e.g. myeloma). Recently bone markers have been found to play an important role in other diseases, like cardiovascular diseases (CVD). Vitamin D, which plays a role in body metabolism, is also an important hormone maintaining bone homeostasis.The aim of the study was to evaluate the levels of bone turnover markers (osteoprotegerin and ICTP) in...

Polycystic ovary syndrome (PCOS) affects more than 5% of women in reproductive age and is characterized by a heterogeneous spectrum of oligoanovulation and biochemical or clinical evidence of hyperandrogenism. Insulin resistance and compensatory hyperinsulinaemia play a significant role in pathogenesis of PCOS.Chronic low level inflammation and an increased risk for cardiovascular disease and type2-diabetes are reported in women with PCOS.<p class="a...

Ceramide (Cer) and sphingomyelin (SM) belong to a family of sphingolipids (SLs). Both SLs are mixtures of many species, differed in length and saturation of the fatty acid chain. Cer and SM are important components of the plasma membrane. In addition, Cer is a cellular second messenger, mediating apoptosis. The altered profiles of blood plasma/serum SLs were found in many pathologies. Interestingly, circulating SLs were proposed to be the early predictors of Alzheimer disease....

Introduction: Results of the first European real-world evidence from retrospective cohort of ACRONIS study previously confirmed the efficacy and tolerability of LA-PAS in heavily pre-treated, uncontrolled acromegaly patients. Here, we report results of the second interim analysis reflecting the prospective cohort.Methods: Patients who were treated with LA-PAS for ≥6 months were included in this analysis. The primary objective was to document treatm...

Differentiated thyroid carcinoma (DTC) is viewed as an indolent disease but 5–15% of patients (pts) become refractory to RAI treatment. This is associated with poor prognosis, a 3–6 years life expectancy and accounts for approximately 200 deaths per year in Canada. There is no universal definition of rDCT and management evolves over time, with either monitoring or systemic therapy including LEN. In the Select Study on LEN in DTC, LEN provided a 19.4 month (mo) medi...