Endocrine Abstracts

Issues: No specific centre in asia for Osteoporosis patients treatment/rehabilitation. We used locally available Complementary Indian Medicines [CAM] for providing home based care in rural/tribal areas.Aims: To provide CAM to poor patients in collaboration with Traditional-faith-hearers. Evaluated cost-efficacy of CAM & response of pain of fractures to CAM alongside analgesics.Methods: from April 2014 to November 2018, 122 pati...

Issues: In developing nations diagnosis of diabetes brings mental-trauma/depression in family. Focused treatment for pediatric age-group is unavailable in developing-countries. 26% of diagnosed diabetics are children’s. Adequately trained physicians/Nurses in issues of pediatric-diabetes provide continuity of care, relief from depression and smooth transition from diagnosis to treatment. Qualitative collaborative relationship between these makes diabetics life bearable. O...

Background: Despite a wealth of gene-discovery studies identifying recurrently mutated genes in hereditary and sporadic endocrine tumours, the molecular mechanisms underpinning tumourigenesis frequently remain ill-defined, in part reflecting a lack of physiologically relevant model systems to investigate gene function. Here, using pancreatic neuroendocrine tumours as an example, we explored the utility of human induced pluripotent stem cell (iPSCs) and CRISPR/Cas9 gene-editing...

Background: Despite a wealth of gene-discovery studies identifying recurrently mutated genes in hereditary and sporadic endocrine tumours, the molecular mechanisms underpinning tumourigenesis frequently remain ill-defined, in part reflecting a lack of physiologically relevant model systems to investigate gene function. Here, using pancreatic neuroendocrine tumours as an example, we explored the utility of human induced pluripotent stem cell (iPSCs) and CRISPR/Cas9 gene-editing...

Introduction: Germline and somatic inactivating MEN1 variants are associated with a wide range of inherited and sporadic endocrine tumours. MEN1 encodes the tumour suppressor Menin, a ubiquitously expressed scaffold protein, implicated in multiple cellular processes including transcription, epigenetic regulation, and modulation of key signaling pathways. Despite intensive study, the mechanisms leading to endocrine tumorigenesis remain ill-defined, in part ref...

Introduction: Covid -19 can cause serious or severe illness in anyone but those with chronic health conditions are at greater risk. Adrenal insufficiency (AI) is assumed to be associated with an increased Covid-19 infection risk, which could trigger an adrenal crisis. We conducted a retrospective study at district general hospital to assess the incidence of COVID-19 in Adrenal insufficiency patients.Method and material: Retrospective review of 43 patient...

Liquorice is a sweetener found in many food products, soft drinks, snacks and herbal medicines. Liquorice ingestion is an uncommon cause of AME or pseudohyperaldosteronisim. The mechanism involves the inhibition of 11-beta-hydroxysteroid dehydrogenase type-2 by the active ingredient called glycyrrhizin, which leads to the uninhibited activation of mineralocorticoid receptors by cortisol. Confectionary products that contain liquorice are readily available in the European Union....

Background: The global incidence of pancreatic neuroendocrine tumors (PanNETs) has witnessed a steady rise in the past three decades. Unfortunately, the survival rates remain low primarily due to late-stage diagnoses and a lack of specific and sensitive diagnostic markers. Therefore, there is an urgent need for improved and efficient early diagnostic biomarkers. Small extracellular vesicles (sEVs) have gained significant attention in the field of tumor growth and cancer metast...