Endocrine Abstracts

Introduction: It is well established that acromegaly is associated with increased risk of cancer. However, it is currently unclear whether patients with acromegaly are at increased risk of developing adrenal tumors and little is known about the association between acromegaly and adrenal adenomas. The simultaneous occurrence of preclinical Cushing’s syndrome in patients with acromegaly and adrenal adenoma is extremely rare, and to our knowledge, so far only 5 such cases ha...

Introduction: Atypical pituitary adenomas are tumors refractory to conventional therapy and characterized by a tendency to rapid progression and high recurrence rate. The aim of the study was to summarize our experience in treatment of atypical pituitary adenomas with temozolomide (TMZ).Material: 5 patients (3F;2M) aged 44–58 (mean 52.4±5.4) years treated in 2013–2016. We analyzed the results, tolerance and side effects of TMZ.<p class...

Introduction: In 7–20% of cases, Cushing’s disease is due to ACTH-producing macroadenoma. Aim of the study was to present our observations concerning etiologic, clinical, and therapeutic diversity of Cushing’s disease in patients with macrocorticotropinomas.Material and methods: Retrospective analysis of medical records of nine patients (5F; 4M) hospitalized in 2002–2015.Results: Four of the patients (2F; 2M) we...

Introduction: Severe hyponatremia defined as the blood sodium concentration below 115 mmol/l is rarely recognised in the course of autoimmune polyglandular syndrome type 2 (APS t.2). The aim of the paper is to present the female patient with severe hyponatremia preceding the diagnosis of APS t.2 of atypical clinical picture.Case report: A 54-year-old woman with the diagnosis of psoriasis established 10 years earlier and treated for psoriatic arthritis fr...

Background: Meningitis coexisting with pituitary macroadenoma is rarely observed. It occurs either as a primary meningitis (primary tumor manifestation), or as a secondary meningitis (after neurosurgery or reduction of the volume of the tumor which has destroyed the sellar floor or the skull base).Objective: Case reports of two patients with the concomitance of secondary meningitis and pituitary macroadenoma.Case 1: A 36-year-old m...

The factors influencing the final outcomes of 131I therapy are indefinitely known, besides its practical use since more than 60 years. One of the considered factors affecting the results of 131I therapy is iodine metabolism.Aim: The aim of the study was the evaluation of the iodine uptake and the effective half-life of 131I influence on the result of radioactive iodine therapy in patients treated due to Graves’ hyper...

The current PDA recommendations relating to the good metabolic control of diabetes are: self-controlled fasting blood glucose (FBG)70–90 mg%, HbA1c ≤6.1%, lipid profile (LP) TChol ≤175 mg%, LDL≤100 mg%, HDL ≥40 mg%, TG≤150 mg%.Objective: To evaluate the accomplishment of the proper metabolic control in diabetic outpatients with regard to the PDA guidelines.Material and Methods: a548 diabetics (249...

Introduction: Insulinomas are usually singular adenomas <1 cm. Less than 5% have diameter >3 cm. Multiple adenomas frequency is estimated on 3 do 9%. Malignant insulinomas are diagnosed in 3–6% patients. The oldest patient with insulinoma described in literature was 95 years old. About 30–50% of patients are previously misdiagnosed.Aim of the study: The aim of the study was presentation of patients with rare clinical characteristics of ...

Introduction: WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla. Almost all pheochromocytomas produce catecholamines. An annual incidence of this tumor in the general population is estimated at 3–8 cases/million/year. 40–50% of patients with pheochromocytoma are characterized by sustained hypertension, a similar percentage – only by paroxysmal hypertension and up to 10% are normotensiv...

Introduction: ACTH-secreting macroadenomas account for about 4–10% of Cushing’s disease and are often resistant to surgical treatment and radiotherapy. The aim of the study was to present diagnostic and therapeutic difficulties in a case of cyclic recurrent ACTH-dependent Cushing’s syndrome due to atypical pituitary adenoma.Case report: 50-year-old man with visceral obesity was referred to hospital because of poor control of diabetes and h...