Endocrine Abstracts

The patients with polycystic ovary syndrome (PCOS) are at increased risk for insulin resistance, central obesity, dyslipidemia and hypertension. In our study, we aimed to detect whether women with PCOS who had normal OGTT results have had insulin resistance. Moreover we investigated the association of probable insulin resistance with cardiovascular risk indicators such as hs-CRP and carotid intima media thickness (CIMT).In total, 34 untreated PCOS patien...

Obesity is due to the combined effects of genetic, environmental, lifestyle and the interactions of these factors. Leptin (LEP) is an adipocyte-derived hormone that acts to reduce food intake and increase energy expenditure by binding and activating its specific receptor in the hypothalamus. In humans, LEP and LEPR have been mapped to 7q31.3 and lp31, respectively. The LEP and LEPR genes have been investigated in the search for gene variants potentially related to the pathophy...

Overt hypothyroidism is associated with an increased risk for cardiovascular disease. We aimed in this study, to assess the changes in renal function, serum lipids, vitamin B12, folate and homocysteine levels before and after treatment in hypothyroid patients.Fifty-four (male/female;7/47) hypothyroid patients enrolled to study. We measured homocysteine(tHcy), total cholesterol(TC), triglyceride(TG), HDL-cholesterol (HDL-C), creatinine, folic acid, and vi...

Introduction: We aimed to evaluate the relationship between platelet count and metabolic risk factors in over weight and obese women in Turkish women.Methods: Over weight (BMI>25 kg/m2) 665 and obese (BMI>30 kg/m2) 4609 women were enrolled into the study. The patients were divided into three group according to the platelet count (PLT), Group I (n=1724) consist of serum PLT≤245×103, group II (n...

Introduction: Hypertension is a major risk factor for several cardiovascular diseases including coronary heart disease. Prehypertension is defined systolic blood pressure (SBP) between 120–139 mmHg and diastolic blood pressure (DBP) 80–89 mmHg. Recent studies have documented an increased risk of cardiovascular disease in persons with prehypertension. In this study, we evaluated association between prehypertension and the metabolic risk markers in over weight and obes...

Introduction: Elevated levels of the inflammatory markers are associated with increased risk for CVD and diabetes mellitus. There is accumulating evidence indicating that inflammatory markers as C-reactive protein (CRP) is associated with insulin resistance. The aim of the study is to evaluate the correlations between serum inflammatory markers and plasma fasting glucose (PFG) in overweight and obese women.Methods: Overweight (25<BMI<30 kg/m...

Introduction: This study carried out relationship between glomerulary filtration rates (GFR) and various metabolic parameters in obese women.Materials and methods: Selected subjects recruited retrospectively from outpatient clinic for this study were 5115 overweight or obese women with mean GFR which was 93 ml/dk/1.73 m2 calculated by MDRD (modification of diet in renal disease). According to mean GFR, they divided group I (low GFR) having &#8...

Introduction: Elevated high-sensitive c-reactive protein (hs-CRP) in association with hyperinsulinemia, obesity, insulin resistance and high blood pressure are significant risk factors for cardiovascular diseases. The aim of this study is to evaluated the correlations between serum hs-CRP concentration and metabolic risk factors in overweight and obese women.Methods: Overweight (BMI>25 kg/m2) and obese (BMI>30 kg/m2) 755 wom...

Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves’ disease (GD) in different ethnic groups.The aim of the present study was to investigate the relationship of IL-6, IL-10, TNF-α, TGF-β, and INF-γ gene polymorphisms with the development of GD in Turkish population. A total of 224 subjects were included in the study comprising of 1...

Homozygous familial hypercholesterolemia (HoFH) represents a potentially fatal condition that is caused by low density lipoprotein (LDL) cholesterol receptor deficiency. Statins alone are not effective in HoFH. In recent years, semiselective or selective LDL cholesterol apheresis systems have been shown to prolong life. However, applying LDLC apheresis therapy, recent evidence also suggests that more intense LDL cholesterol reduction is associated with more clinical benefit. E...