Endocrine Abstracts

Introduction: Disturbances of the thyroid gland are the most common diseases of the endocrine system. Their prevalence is increasing with age and can be easily under diagnosed. Advanced forms of thyroid disease can mimic cardiovascular, psychiatric disorders, malignancy or other disorders and can result in life threatening conditions.Case reports: In the current study we present two case reports concerning patients with cardiovascular symptoms. In both p...

Background and aims: The fat mass and obesity associated gene (FTO) was identified as a gene with strong obesity related traits nevertheless the exact mechanism is still unknown. Our aim was to study the possible effects of FTO risk haplotype on anthropometric data and metabolic and hormonal parameters in lean women (to eliminate the influence of BMI) and to evaluate the effect of hormone contraception (HC).Materials and methods: The SNPs r...

Melanocortin-4 receptor (MC4R) gene is expressed in the brain and has been implicated in mediating most of the effects of melanocortin on food intake and energy expenditure. Common variants of MC4R gene are associated with fat mass, weight, risk of obesity and insulin resistance in several populations.We investigated if rs12970134 A/G is associated with obesity and studied its possible metabolic effects.Polymorphism was assesed by ...

Detailed information on adrenal function in autoimmune Type 1 diabetes with onset in adults is still lacking. This work aimed at gathering own data on adrenal response to low-dose (1 μg) ACTH in blood and saliva.Twenty-three diabetics were investigated; age 44±10 yrs (mean ± S.D.), age at diagnosis 28.5±10 yr, disease duration 15±8 yr, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%....

KCNJ11 as well as UCP2 genes are involved via modulation of ATP concentration in pancreatic beta-cells in control of insulin secretion. The aim of study was to compare genotypic distribution of E23K (KCNJ11) and G-866A (UCP2) polymorphisms between diabetics, their offspring and controls and to study the possible association of these polymorphisms with biochemical and anthropometric parameters.The study entered 302 diabetics, 165 offspring, 241 controls. ...

Introduction: The SNP rs7578597 (Thr1187Ala) of THADA gene was identified in GWA studies as a novel type 2 diabetes risk locus. Nevertheless, subsequent studies of this SNP effect have been inconclusive. In some studies, rs7578597 has been associated with insulin secretion but no significant correlation with type 2 diabetes has been reported. Product of THADA gene is considered to be involved in apoptosis. Whether rs7578597 affects insulin secretion throught the apoptosis of p...

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Adipokines and pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between adiponectin, resistin, leptin, interleukin (IL) 4, IL6, IL10, tumor necrosis factor α (T...

Detailed information on adrenal function in autoimmune Type 1 diabetes with onset in adult age is still missing. This work compared diabetics with low response (LR) to diabetics with normal response (NR) to low dose ACTH test and control group (C).Thirty-two diabetics were investigated; LR (n=16), NR (n=16), age 44±10 years (mean±S.D.), age at diagnosis 28.5±10 years, disease duration 15±8 years, BMI 24.5&...

The relationship of insulin resistance, androgens and endothelial dysfunction in polycystic ovary syndrome ,PCOS, is controversial till now. We evaluated if ICAM-1 levels differ between PCOS and healthy women and whether this marker of the early endothelial damage is associated with the particular metabolic and/or hormonal characteristics.After signing written informed consent, 39 PCOS women -median of age 25 yrs, BMI 24.9 and 10 age matched healthy wome...