Endocrine Abstracts

Laszlo Hegedüs, University of Southern Denmark, Odense, Denmark AbstractLaszlo Hegedüs is Professor of Endocrinology at University of Southern Denmark, in Odense and Consultant Endocrinologist at the Department of Endocrinology and Metabolism, Odense University Hospital. His thesis for Doctor of Medical Science (1990) is entitled: ‘Thyroid size determined by ultrasound. Influence of physiological factors...

The treatment of benign multinodular goitre (MNG) is controversial, but surgery is recommended for large compressive goitres in contrast to observation in small to medium sized MNG. While some patients decline surgery others have contraindications due to comorbidity. Therefore, non-surgical treatment alternatives are needed. Until recently, levothyroxine therapy was the preferred non-surgical alternative. But due to low efficacy and potential side-effects, international guidel...

The prevalence of overt autoimmune thyroid disease (AITD) is no less than around 2–3% in the adult population and increases with age. Subclinical thyroid autoimmunity is around 10 times higher, with a female preponderance. Although the major phenotypes (Graves’ disease, Hashimoto’s thyroiditis – with or without goitre, and chronic asymptomatic thyroiditis) are well characterized our knowledge of the aetiology of these disorders is incomplete. Studying twins...

Background: Meta-analyses have questioned whether mortality is increased in hyper- and hypothyroid individuals, and if so the magnitude. This is mainly due to inadequate size of study populations, differences in study design and participant characteristics, lack of control for confounders and whether the participants are treated.Materials: Using record-linkage data from nationwide Danish health registers, and after adjustment for preexisting morbidity, a...

The V2 vasopressin receptor (V2-R) mediates the effect of vasopressin on the water reabsorption in the kidney and several mutations in the V2-R have been identified causing nephrogenic diabetes insipidus (NDI). In this study, we investigated a previously not characterized mutation of the. We obtained genomic DNA of a young male patient with NDI, the AVPR2 gene was amplified with PCR and a missense mutation (S127F) was identified. We monitored the cellular localization of the S...

Introduction: The Warthin-like variant of papillary thyroid cancer (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumours of the salivary glands, and more commonly associated with Hashimoto’s thyroiditis than other types of PTCs. The WLPTC is characterized by papillae lined by large oncocytic cells with cores having dense lymphoplasmacytic infiltrate. The prognosis of WLPTC is the same or less aggressive than that of classical PTC, but i...

Introduction: The thyroid is a multifunctional endocrine gland which, by its hormones, affects all the organs, metabolisms and nonspecific defence of the body. The aim of this study is to establish if endogenous thyroxin (FT4) is involved in the nonspecific defence of the organism.Material and methods: 94 patients were included in the study, 47 with hyperthyroidism and 47 with hypothyroidism, 81 women, 13 men aged 7–78. FT4 was...

The concentrating function of the kidney is important to maintain the water homeostasis of the body. It is regulated by the arginine-vasopressin system through the type 2 vasopressin receptor (V2R). Loss-of-function mutations of V2R in kidney can lead to nephrogenic diabetes insipidus (NDI) which results several symptoms such as polyuria, polydipsia, and hyposthenuria. In this study, we functionally characterized and investigated the potential rescue of a missense mutation (S1...

Already a long time ago, the subtle adaptability of the reproductive endocrine system made it possible to elaborate a hormonal castration method for female pigs, which was based on the administration of a high-dose oestrogen (diethylstilboestrol) injection. The phenomenon was believed to be the result of a negative feedback reaction. However, this theory could not explain why more than 20% of the animals treated did not respond properly to the treatment. Therefore, the goal of...

Patients with insulin resistance are often confronted with conception difficulties. Our database of 1178 conceivable female patients with metabolic disorder shows that more than 40% of them suffer from menstrual cycle disorders. More than 25% out of 480 pregnant women with hyperinsulinaemia had at least one assisted reproduction procedure in their lives. 42% of patients with insulin resistance experienced missed abortion, out of them 26% one time, 12% two times. Our aim was to...