ea0011p379 | Diabetes, metabolism and cardiovascular | ECE2006
Padmanabhan S
, Fraser R
, Ingram M
, Davies E
, Munroe PB
, Dobson R
, Brown M
, Samani N
, Clayton D
, Farrall M
, Webster J
, Lathop M
, Caulfield M
, Dominczak AF
, Connell JM
Background: Glucorticoids can affect blood pressure in humans, as demonstrated most strikingly in Cushings syndrome. We have previously reported that total cortisol metabolite excretion is raised in obese subjects, while other investigations have identified genetically determined changes in glucocorticoid receptor function as contributors to hypertension. Furthermore, in essential hypertension, vasoconstrictor sensitivity to glucocorticoids is increased. Such raised sens...