Searchable abstracts of presentations at key conferences in endocrinology

ea0011p571 | Growth and development | ECE2006

Mortality in growth hormone deficiency

Stochholm K , Gravholt C , Laursen T , Sandahl J , Green A

Aim: We aimed to describe mortality for both gender in children and adults, in Growth Hormone Deficiency (GHD).Materials and methods: Using three national registries: The Causes of Death Registry, The National Patient Registry, and The Cancer Registry, and The International Classification of Diseases as a filter, we identified a primary cohort of 9,131 patients. All had a high a priori risk of having GHD. All available hospital files (representing 90.2% ...

ea0065s3.2 | Phosphate homeostasis physiology, pathology and pharmacology | SFEBES2019

Phosphate-sensing update: interplay between FGF23, phosphate, and phosphate-sensors

Bon Nina , Beck-Cormier Sarah , Beck Laurent

Despite significant progress in understanding the regulation of phosphate (Pi) homeostasis over the past 20 years, the mechanisms underlying the very early step leading to the regulating cascade involving multiple hormones (PTH, vitamin D, FGF23) and organs (kidney, intestine, bone, parathyroid glands) are not deciphered. Progress in this area is based on on the ability to identify and characterise the Pi-sensing mechanism in mammals that allow cells or organisms to detect cha...

ea0032p464 | Diabetes | ECE2013

Effects of human insulin and insulin aspart preparations on levels of IGFI, IGFBPs and IGFI bioactivity in patients with type 1 diabetes

Ma Zhulin , Christiansen Jens Sandahl , Lauritzen Torsten , Parkner Tina , Laursen Torben , Frystyk Jan

Introduction: Type 1 diabetes (T1D) is characterized by primary insulin insufficiency and secondary disruption of GH–IGF–IGFBP axis. S.c. insulin therapy is necessary to normalize this axis. This study aimed to investigate whether the distinct insulin profiles obtained with insulin aspart and human insulin preparations, respectively, affect IGF1 concentration and bioactivity and IGFBP levels differently.Methods: In a randomized, four-period cro...

ea0029p723 | Diabetes | ICEECE2012

A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50 and human insulin: a randomized, quadruple crossover study

Ma Z. , Parkner T. , Frystyk J. , Laursen T. , Lauritzen T. , Christiansen J.

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

ea0056p19 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal insufficiency during prednisolone treatment in patients with polymyalgia rheumatica or giant cell arteritis – prevalence and clinical approach

Willemoes Borresen Stina , Laursen Toke , Jensen Bente , Hilsted Linda , Marie Bartels Else , Feldt-Rasmussen Ulla , Locht Henning

Introduction: Prednisolone is standard treatment of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), but many patients are reluctant to discontinue prednisolone treatment even after remission of the inflammatory conditions. Prednisolone-induced adrenal insufficiency can give manifest or latent symptoms, causing failure to taper and withdraw prednisolone. We therefore aimed to find the prevalence of adrenal insufficiency in prednisolone-treated patients with PMR/GCA...

ea0064015 | Impaired Hypoglycemia Awareness in children and adolescents with type 1 diabetes | BES2019

Impaired hypoglycemia awareness in children and adolescents with type 1 diabetes

Anissa Messaaoui , Sylvie Tenoutasse , Lucia Hajselova , Laurent Crenier

Aim of the work: Impaired Hypoglycemia Awareness (IHA) is associated with an increased risk of Severe Hypoglycemia (SH) in adults with diabetes but is less known in youth. The purpose of this study was to determine the prevalence of IHA and its clinical characteristics in a cohort of children and adolescents with type 1 diabetes.Methods: This prospective observational study of two-month duration included all eligible subjects with type 1 diabetes attendi...

ea0032p898 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Receptor expression in craniopharyngiomas causing tumor growth in pregnancy: case report and review of the literature

Monica Tome , Laurent Vroonen , Albert Thiry , Adrian Daly , Albert Beckers

Introduction: Generously supported by IPSEN)-->Craniopharyngiomas (CP) are benign tumors that arise from remnants of the Rathke’s pouch. Classically, they are classified as cystic or calcified tumors. The presence of hormonal receptors in CP has been reported in in vitro studies but only eight cases growing during pregnancy have been published in literature.Case report: We report a 32-year-old wom...

ea0020p291 | Clinical case reports and clinical reports | ECE2009

The R106C mutation of the V2 vasopressor receptor gene (AVPR2) causing X linked congenital nephrogenic diabetes insipidus is responsive to short term desmopressin challenge

Fysekidis Marinos , Boffa Jean-Jacques , Baud Laurent , Haymann Jean-Philippe

Background and aims: Patients with AVPR2 gene mutations present nephrogenic diabetes insipidus (NDI) resulting to a severe deficit in urine concentration despite high levels of circulating Antidiuretic Hormone (ADH). The mutation in codon 106 of the AVPR2 gene leading to the substitution of arginine by cysteine (R106C) is known to produce a mild disease while in vitro characterization revealed a complete loss of function. We report the case of a 24-year-old male member ...

ea0057020 | Epidemiological, biochemical, genetical aspects of pheochromocytomas and paragangliomas followed in CHU of Liege between 1993 and 2017 | BES2018

Epidemiological, biochemical, genetical aspects of pheochromocytomas and paragangliomas followed in CHU of Liege between 1993 and 2017

Sandrine Petignot , Laurent Vroonen , Etienne Hamoir , Etienne Creemers , Albert Beckers

Object: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors that are responsible for an inappropriate production of catecholamines. They are heritable in 40% of cases and can integrate different genetic syndroms. Thus, there are several interests to detect them precociously: avoid comorbidities due to the catecholamine hypersecretion, search syndroms and manage their related manifestations and screen the families. The objectives of this study were to separate PPGLs in...

ea0071022 | Soft drink intake on time of hypoglycaemia during insulin tolerance test: Effects on pituitary response and comfort for the patient | BES2020

Soft drink intake on time of hypoglycaemia during insulin tolerance test: Effects on pituitary response and comfort for the patient

Coralie Thiry , Laurent Crenier , Fleur Wolff , Bernard Corvilain , Agnes Burniat

Background and aim: Insulin tolerance test (ITT) is the gold standard for the diagnosis of cortisol and growth hormone deficiencies in adults. Once hypoglycaemia (<40 mg/dl) is achieved, some medical centers give sugar to their patients (food, drink or glucose infusion), others do not and let the blood glucose rise spontaneously. Although critical hypoglycaemia results in discomfort and potential complications for the patients there is so far no recommendation on the subje...