Searchable abstracts of presentations at key conferences in endocrinology

ea0003p281 | Thyroid | BES2002

Delayed resolution of endothelial dysfunction despite biochemical correction of thyrotoxicosis

Obuobie K , Evans S , Lazarus J

Endothelial dysfunction contributes to the cardiovascular complications in Diabetes mellitus and hypertension. The effects of hyperthyroidism on the peripheral vasculature are not fully understood. Decreased central arterial stiffness is a feature of thyrotoxicosis and normalises with treatment (1). The purpose of our study was to establish the effect of thyrotoxicosis and its treatment on surrogate humoral markers of endothelial function; Von Willebrand factor (VWF), Soluble ...

ea0037s21.2 | Thyroid hormone in pregnancy | ECE2015

Consequences of maternal thyroid dysfunction for offspring

Lazarus John

Treatment of hyperthyroidism with antithyroid drugs has recently been shown to have an effect on MMI/Carbimazole embryopathy at a specific early window in gestation. This has important implications for management.There is agreement that untreated overt gestational hypothyroidism is associated with significant adverse obstetric and fetal/neonatal effects. Although there is also substantial evidence that gestational subclinical hypothyroidism (SCH) is asso...

ea0029s52.1 | Thyroid & Pregnancy | ICEECE2012

Outcome of the controlled antenatal thyroid screening study

Lazarus J.

Fetal brain development depends on thyroid hormone and children born to mothers with low thyroid hormone levels have decreased cognitive function. Nineteen per cent of children born to mothers known to have a high TSH during gestation had an IQ <80 compared to 5% of children born to mothers known to have normal TSH levels in pregnancy (P<0.001; Haddow et al. 1999).We conducted a randomized trial of antenatal hypothyroidism screening...

ea0012s7 | Thyroid at the beginning and end of life | SFE2006

Management of thyroid disease in pregnancy

Lazarus JH

Thyroid function hormone concentrations change during pregnancy. There is also a reduction in antibody titre and an increase in T helper-2 (Th2) immune responses. Thyroid antibodies (TPOAb) are associated with an increased risk of miscarriage but levothyroxine administration can reduce both miscarriage and premature delivery rates. Gestational hyperthyroidism may be due to hyperemesis gravidarum or GravesÂ’ disease. Management of GravesÂ’ hyperthyroidism is with antith...

ea0006s18 | This house believes that the investigation of thyroid nodules should be simplified to a syringe and needle | SFE2003

The case against

Lazarus J

There is no doubt that the use of a syringe and needle has led to an important cost effective strategy for the investigation of thyroid nodules by fine needle aspiration biopsy (FNAB) with cytological examination of the aspirate. A recent European Thyroid Association survey found that 99% of respondents used FNAB (Bennedbaek et al 1999). However, there are limitations of FNAB including false negatives, false positives, inadequate specimens and reporting, accessibility of nodul...

ea0007p241 | Thyroid | BES2004

The evaluation of arterial stiffness in subclinical hypothyroidism

Owen P , Lazarus J

The cardiac effects of subclinical hypothyroidism (SCH i.e. increased circulating TSH with normal T4) have been documented. While overt hypothyroidism causes increased central arterial stiffness (CAS) and augmentation gradient (AI) 1, there are only limited data in SCH. We have measured CAS, AG and augmentation Index (AI) (AG/Pulse pressure x 100) in patients with SCH before and after L-thyroxine (synthroid) therapy.Peripheral pulse pressure w...

ea0009p167 | Thyroid | BES2005

Evaluation of thyroid hormone replacement therapy with two different thyroid preparations

Owen P , John R , Lazarus J

ObjectiveThyroid replacement therapy needs careful titration, and recently there has been discussion regarding the bioavailability of different thyroxine preparations [1]We have taken the opportunity of comparing thyroid function in 18 females who were enrolled in a trial studying the effects of thyroxine therapy on subclinical hypothyroidism [SCH].MethodsThese patients (at entry to tri...

ea0007oc20 | Thyroid | BES2004

Steroid modulation of peripheral cytokine expression: increased resistance to dexamethasone and progesterone inhibition of type 1 CD4+ response in autoimmune thyroiditis

Okosieme O , Premawardhana L , Parkes A , Lazarus J

Glucocorticoids may regulate the autoimmune response by influencing the shift in balance between type-1 and type-2 cytokine responses. To investigate the effect of steroids on peripheral cytokine expression in autoimmune thyroiditis we measured dexamethasone (Dex) and progesterone (Prg) inhibition of peripheral CD4+ T lymphocyte expressions of Interferon-gamma (IFN-g) (type-1 response) and Interleukin-4 (IL-4) (type 2 response) in both patients and healthy subjects.<p clas...

ea0094oc1.5 | Bone and Calcium | SFEBES2023

CTNNB1 pathogenic variants can cause an autosomal dominant osteoporosis-pseudoglioma-like syndrome: a new form of osteogenesis imperfecta?

Lazarus Syndia , Nicolas Boyer Pierre , Duncan Emma

A 27-year-old woman with familial exudative vitreoretinopathy (FEVR) experienced multiple childhood fractures, including wrist (aged 7y), hip (aged 10y) and numerous vertebrae. She had low bone mineral density (BMD) (Z scores < -2.5 at multiple sites aged 9; persistently low BMD as an adult) and was short (height below 1st centile). Other features included an unusual facies and mild intellectual impairment. Her mother also had FEVR, dental hypoplasia, mild intellectual imp...

ea0077p3 | Adrenal and Cardiovascular | SFEBES2021

Improving outcomes from SSTS: Redefining Cortisol Cut-Offs

Choudhury Sirazum , Ramadoss Vijay , Lazarus Katharine , Tan Tricia , Meeran Karim

Background: Short Synacthen Tests (SSTs) are integral to the diagnosis of Adrenal Insufficiency (AI). A 30-minute stimulated cortisol value is assessed against local assay dependent thresholds to ascertain or exclude the diagnosis. A diagnosis of AI is a life changing event requiring the initiation of life long glucocorticoid replacement therapy for survival. Glucocorticoid replacement is associated with long term morbidity and mortality, including an increased risk of diabete...