Searchable abstracts of presentations at key conferences in endocrinology

ea0011p585 | Neuroendocrinology and behaviour | ECE2006

GH secretion in amyotrophic lateral sclerosis

Morselli LL , Bongioanni P , Genovesi M , Licitra R , Rossi B , Martino E

Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disorder in human adults. Scanty data on endocrine abnormalities have been reported. Aim of the present study was to investigate the GH-IGF-I axis in ALS patients.22 ALS patients (12 men and 10 women), aged 46–77 years, performed GHRH+arginine test: blood samples for GH were collected at baseline, 30 and 60 minutes; IGF-I was determined at baseline. The control group consisted of 2...

ea0014p571 | (1) | ECE2007

Riluzole treatment does not affect growth hormone (GH) secretion in amyotrophic lateral sclerosis

Morselli Lisa Linda , Bongioanni Paolo , Genovesi Maura , Licitra Rosaria , Rossi Bruno , Murri Luigi , Gasperi Maurizio , Martino Enio

Amyotrophic lateral sclerosis (ALS), the most common motor neurone disorder in human adults, presents is characterized by selective and progressive degeneration of upper and lower motor neurones in central nervous system. GH secretion, evaluated by GHRH+arginine test, has been recently reported to be impaired in about 70% of untreated ALS patients. The currently available drug for ALS treatment is riluzole, a compound acting through inhibition of glutamate relase, post-synapti...