Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep777 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Erk- and Akt-mediated osteocalcin signaling in human pancreatic β-cells does not directly involve GPRC6A activation

Perego Silvia , Sansoni Veronica , Faraldi Martina , Banfi Giuseppe , Lombardi Giovanni

Osteocalcin (OC) is the main non-collagenous protein of the bone and it has a regulatory role in mineralization. Extra-skeletal roles have been recently hypothesized for OC (e.g., modulation of glucose-induced insulin secretion by interacting with GPRC6A in β-cells). However, OC-mediated GPRC6A activation has been demonstrated only in rodents and heterologous systems. In this study we aimed at evaluating the dose-dependent response to OC and the eventual activation of the...

ea0041ep482 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Unstable expression of GPRC6A in human pancreatic β-cells

Perego Silvia , Sansoni Veronica , Banfi Giuseppe , Lombardi Giovanni

Introduction: GPRC6A is a widely expressed seven-transmembrane G-protein coupled receptor mediating L-α-amino acids signaling (mainly, arginine, lysine, and ornithine), which has been proposed as receptor for osteocalcin. By interacting with GPRC6A, in β-cells, osteocalcin is thought to modulate the glucose-induced insulin secretion. However, GPRC6A functions have been studied only in rodents or in rodents-derived cells.Aim of th...

ea0029p1579 | Thyroid (non-cancer) | ICEECE2012

Short-term combined treatment with L-thyroxine plus L-triiodothyronine in drops (LT4 plus LT3) in patients with persistent hypothyroidism and malabsorption during replacement therapy with L-T4.

Ippolito S. , Arpaia D. , Peirce C. , Lombardi G. , Biondi B.

The objective of our study was to evaluate the potential benefit of short-term combined treatment with LT4plusLT3 in patients with persistent hypothyroidism and malabsorption. We report ten cases of patients with hypothyroidism secondary to total thyroidectomy, in which high doses of L-T4 (2,7-3.5 mcg/kg/die) were not adequate to normalize thyroid function. TSH was persistently high (from 10 to 100 mU/L) with low serum levels of thyroid hormones.<p class="ab...

ea0014oc7.4 | Reproductive endocrinology I | ECE2007

Capacitation and acrosome reaction in human ejaculated spermatozoa involve activation of a novel SRC tyrosine kinase

Varano Gabriele , Lombardi Adriana , Forti Gianni , Baldi Elisabetta , Luconi Michaela

Tyrosine phosphorylation of proteins is one of the main processes associated with the development of some specific functions of ejaculated human spermatozoa. Although this process, as well as the identity of the phosphorylated targets, has been well characterized, only few tyrosine kinases (TKs) have been identified so far. Moreover, their roles in regulating sperm functions are still unknown.In the present work, we report the presence and localization o...

ea0029p328 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of medical therapy on 24-h blood pressure profile in acromegaly

Sardella C. , Nuzzo A. , Urbani C. , Lombardi M. , Scattina I. , Tomisti L. , Martino E. , Bogazzi F.

To investigate the blood pressure profile (BP) in active acromegaly and the effect of medical treatment of acromegaly on BP circadian rhythm, we studied 21 acromegalics before and after 3–60 months of treatment with somatostatin analogs (15/21) or pegvisomant (5/21) or both (5/21). Ambulatory 24-h BP was recorded. The 24-h mean BP (MBP), the mean systolic BP (SBP) and diastolic BP (DBP), the day-time (day) and night-time (night) MBP, SBP and DBP and the 24-h mean heart ra...

ea0029p1398 | Pituitary Clinical | ICEECE2012

Effects of medical therapy of acromegaly on glucose metabolism

Urbani C. , Calevro A. , Scattina I. , Lombardi M. , Sardella C. , Nuzzo A. , Marchello A. , Martino E. , Bogazzi F.

Introduction: Acromegaly is associated with alterations of glucose metabolism. The effect of somatostatin analogues (SMS) and pegvisomant (PEG) on glucose metabolism is still argument of debate.Study design: The purpose of this historical-prospective study was to compare, in a cohort of 47 patients with active acromegaly, the effects of SMS and PEG alone or in combination on glucose metabolism. All subjects were evaluated at baseline and at least 6 month...

ea0029p1465 | Pituitary Clinical | ICEECE2012

Colonic neoplasms in acromegaly: are there serum risk factors?

Lombardi M , Scattina I , Urbani C , Sardella C , Marchello A , Nuzzo A , Dell'Unto E , Martino E , Bogazzi F

Hyperinsulinemia has been associated to an increased risk of colorectal cancer and adenomas, while higher serum 25-hydroxy vitamin D3 and folate seem to reduce the development of colonic lesions in general population. Acromegalic patients have an increased risk of colonic tumors and an association between higher fasting insulin levels and risk of colonic adenomas has been previously demonstrated. No data are available about the influence of vitamin D and folate-homocysteine le...

ea0026p26 | Adrenal cortex | ECE2011

Predictive value of acute cortisol response to cabergoline administration on the responsiveness of cortisol secretion to short and long term treatment with cabergoline

Vitale P , Cozzolino A , De Leo M , Simeoli C , Galdiero M , Lombardi G , Colao A , Pivonello R

Cabergoline (CAB), a potent dopamine agonist, is one of the most effective neuromodulatory drug in the second line treatment of patients with Cushing’s disease (CD). The aim of the current study was to estimate the predictive value of the acute CAB administration on short and long term responsiveness to CAB treatment. Twenty CD patients (6 males, 14 females, 12–60 years) entered the study. The acute CAB test was performed evaluating serum cortisol every hour for 6 h ...

ea0026p73 | Endocrine tumours and neoplasia | ECE2011

68Ga-DOTATATE PET shows a better diagnostic performance than octreoscan in patients with neuroendocrine tumors

Faggiano Antongiulio , Aloi Luigi , Caraco Corradina , Ramundo Valeria , Severino Rosa , Lombardi Gaetano , Colao Annamaria , Lastoria Secondo

Background and objective: 111In-DPTA-Octreotide (Octreoscan) has limited spatial resolution and a somewhat lower receptor affinity of the radiopeptide compared to DOTATATE, a novel somatostatin analogue, which can be radiolabelled with 68Ga and adapted for PET imaging, resulting in an increased spatial resolution. The aim of this study was to evaluate the diagnostic performance of 68Ga-DOTATATE PET in patients with NET and to compare this tecni...

ea0026p226 | Pituitary | ECE2011

Tumor occurrence or recurrence after five year GH replacement theraphy

Savanelli M C , Scarano E , Brunelli V , Lombardi G , Colao A , Di Somma C

GH replacement is widely used in adults with hypopituitarism, but its effect on tumor occurrence and pituitary tumor recurrence is unknown. Furthermore, in literature there are scant with short follow-up time. The available data do not seem to suggest that rhGH replacement increased the incidence of regrowth of pituitary tumor and of cancer in adults with GHD, provided that IGF1 concentrations remain within the normal range for age.The aim of our study w...