Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc1.4 | Thyroid clinical | ECE2007

A novel tyrosine-kinases selective inhibitor with anti-tumoral efficacy (Sunitinib) induces a block in iodine uptake and transient hypothyroidism

Mannavola Deborah , Vannucchi Guia , Carletto Marco , Longari Virgilio , Bertuelli Rossella , Coco Paola , Casali Paolo , Beck-Peccoz Paolo , Fugazzola Laura

Sunitinib (SU11248) is a multitarget inhibitor of tyrosine-kinases (RTK) recently tested in clinical trials for the treatment of some human cancers. Side effects are mostly represented by asthenia and appear in a dose and time correlated manner. After the unexpected observation of a myxedematous coma in a patient affected with GIST and treated with Sunitinib, we evaluated the effect of this drug on thyroid function in 24 patients treated for GISTs Imatinib resistant. Patients ...

ea0011p857 | Thyroid | ECE2006

A novel test with recombinant human TSH for the differential diagnosis of congenital hypothryoidism in pediatric age

Fugazzola L , Weber G , Mannavola D , Vannucchi G , Carletto M , Longari V , Persani L , Beck-Peccoz P

Congenital hypothyroidism (CH) affects 1:2.000–3.000 newborns. In most cases, the cause is a developmental defect (dysgenesia) or an arrested migration (ectopia) of the thyroid gland. In the remaining cases TSH resistance or defects in iodide transport or thyroid hormonogenesis account for CH. The differential diagnosis is aimed to recognize permanent CH forms and to achieve an etiologic diagnosis for accurate management and genetic counselling. Appropriate investigations...

ea0081rc11.1 | Rapid Communications 11: Thyroid 2 | ECE2022

Impact of Covid-19 disease on thyroid function: longitudinal study

Muller Ilaria , Varallo Matteo , Daturi Anita , E Re Tiziana , Dazzi Davide , Longari Virgilio , Gori Andrea , Mantovani Giovanna , Arosio Maura , Salvi Mario

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) affects thyroid function with different mechanisms: non-thyroidal illness syndrome (NTIS), direct infection of thyroid gland and cytokine storm. We provided the first description of painless atypical thyroiditis coexisting with NTIS in patients hospitalised for moderate-to-severe Covid-19 disease. We aimed to: 1) correlate thyroid dysfunction with Covid-19 disease severity;...

ea0073aep651 | Thyroid | ECE2021

Evolution of SARS-CoV-2 related atypical thyroiditis

Muller Ilaria , Re Tiziana , Varallo Matteo , Daturi Anita , Cannavaro Daniele , Nadiani Benedetta , Dazzi Davide , Longari Virgilio , Cuzzocrea Marco , Gori Andrea , Mantovani Giovanna , Arosio Maura , Salvi Mario

BackgroundWe provided the first description of thyrotoxicosis due to atypical thyroiditis in patients hospitalised for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19), not associated with neck pain, more common in men, correlated with disease severity and coexisting with non-thyroidal illness syndrome. Classic viral subacute thyroiditis is often followed by permanent thyroid dysfunction and autoimmunity, thus we h...