Searchable abstracts of presentations at key conferences in endocrinology

ea0044p60 | Bone and Calcium | SFEBES2016

Would a 10% fracture risk threshold for direct access to dual energy densitometry (DXA) exclude patients with low bone mineral density?

Wilson Clare , Loughrey Paul , Cummings Bernie , McNally Colette , Lindsay John

The SIGN guideline group recently suggested a fracture risk threshold of 10% as an indication for DXA. Patients who do not have a 10 year fracture probability of 10% or more would therefore not meet the criteria for direct access to DXA. In order to assess whether implementing these guidelines would impact overall management, we undertook a prospective audit of our direct access DXA and health promotion service. Charts from 61 consecutive patients were reviewed (54F/7M, Mean a...

ea0067o31 | Oral Presentations | EYES2019

Onset of radiation-induced hypopituitarism in pituitary adenomas

Seejore K , Tudawe G , Mansoor T , Lynch JM , Orme SM , Phillips N , Loughrey C , Murray RD

Objective: Radiotherapy (RT) can achieve tumour control rates of over 90% in pituitary adenomas. The commonest toxicity of irradiation is hypopituitarism. The exact incidence is variable and requires long-term testing for deficiency of all hypothalamic-pituitary axes (HPA). The aim of this study is to determine the time to onset of individual hormonal deficiencies and establish a timeframe for endocrine testing post-RT.Methods: We retrospectively assesse...

ea0094p91 | Neuroendocrinology and Pituitary | SFEBES2023

A novel AIP deletion emphasising the variable phenotype of AIP-related pituitary neuroendocrine tumours

Benjamin Loughrey Paul , J Morrison Patrick , K Ellis Peter , R Mullan Karen , Korbonits Marta

A 16-year-old female presented with secondary amenorrhoea. Menarche was age 14 years and periods were less frequent over the preceding 12 months. There was no galactorrhoea, headache or visual field disturbance and no known family history of pituitary disease, tall stature or infertility. There were no clinical signs of Cushing’s disease or acromegaly and visual fields were full to confrontation. Height was 160 cm. Investigations showed a prolactin of 2,452 mIU/l (RR 102-...

ea0038p151 | Neoplasia, cancer and late effects | SFEBES2015

Pituitary-related outcomes of cranial radiotherapy (cXRT) in adults with gliomas

Kyriakakis Nikolaos , Lynch Julie , Orme Steve M , Gerrard Georgina , Hatfield Paul , Loughrey Carmel , Short Susan C , Murray Robert D

Introduction: Radiation-induced hypopituitarism has been well-described in childhood-onset brain tumour survivors, however in adults has received less attention. The aim of this study was to assess the pituitary-related outcomes following cXRT in adults with extra-sellar gliomas.Methods: We retrospectively collected longitudinal data regarding pituitary-related outcomes from medical records of 59 patients, diagnosed with extra-sellar gliomas in adulthood...

ea0038p156 | Neoplasia, cancer and late effects | SFEBES2015

Adverse metabolic profile in long-term survivors of adult and childhood-onset brain tumours: the role of growth hormone deficiency

Lynch Julie , Kyriakakis Nikolaos , Kumar Satish S , Ajjan Ramzi , Gerrard Georgina , Loughrey Carmel , Glaser Adam , Murray Robert D

Introduction: Childhood-onset brain tumour (CO-BT) survivors demonstrate elevated standardized mortality rates for cardiac disease. Adverse lipid profile and body composition contribute to the increased cardiovascular risk. Little is known about the metabolic changes in long-term survivors of adult-onset brain tumours (AO-BT).Methods: We performed a cross-sectional study to compare cardiovascular risk parameters in CO-BT with AO-BT survivors and healthy ...

ea0037gp.16.05 | Diabetes and obesity–Clinical obesity and cardiovascular | ECE2015

Evaluation of cardiovascular risk factors in long-term survivors of brain tumours who received cranial irradiation

Kyriakakis Nikolaos , Kumar Satish S. , Lynch Julie , Ajjan Ramzi , Glaser Adam , Gerrard Georgina , Loughrey Carmel , Murray Robert D.

Introduction: There is strong evidence that adult survivors of childhood cancer have excess premature vascular morbidity and mortality, the pathophysiological mechanism of which remains unresolved.Methods: We undertook a cross sectional study to assess cardiovascular risk in long-term survivors of brain tumours following cranial irradiation compared with healthy matched controls. The following cardiovascular markers were measured: full lipid profile, fas...

ea0037gp.20.04 | Pituitary – Hypopituitarism | ECE2015

Irradiation-induced hypopituitarism in adult brain tumour survivors: single-centre longitudinal data

Kyriakakis Nikolaos , Lynch Julie , Short Susan C , Hatfield Paul , Loughrey Carmel , Gerrard Georgina , Orme Steve M , Murray Robert D

Introduction: Radiation-induced hypopituitarism is a well-recognized complication of cranial radiotherapy (cXRT) for childhood brain tumours when the hypothalamo–pituitary axis is within the irradiation field. Few data are available for survivors of adult brain tumours who have received cranial irradiation.Methods: We retrospectively reviewed medical records of patients referred to Endocrinology following cXRT for primary non-pituitary brain tumours...

ea0086p97 | Neuroendocrinology and Pituitary | SFEBES2022

Aberrant cyclic GMP-AMP synthase stimulator of interferon genes signalling in an AIP mutant cell line

Benjamin Loughrey Paul , Suleyman Oniz , Begalli Federica , Craig Stephanie G , Hunter Steven J , McArt Darragh G , James Jacqueline A , Haworth Oliver , Barry Sayka , Korbonits Marta

Background: The cyclic GMP-AMP synthase stimulator of interferon genes (cGAS-STING) signalling pathway is an element of the innate immune response and is activated by the presence of DNA in the cytosol. Triggering of this immune response may occur in the setting of infection or neoplasia. Activation of this pathway results in phosphorylation of interferon regulatory factor 3 and downstream transcription of cytokines such as interferon β and interleukin-6. Polyinosinic:pol...

ea0086p106 | Neuroendocrinology and Pituitary | SFEBES2022

Identifying and characterising variants in patients with pachydermoperiostosis

Angurala Ishita , Barry Sayka , Rice Tom , Magid Kesson , Rai Ashutosh , Benjamin Loughrey Paul , Dutta Pinaki , Stelmachowska Banaś Maria , Korbonits Marta

Introduction: Pachydermoperiostosis (primary hypertrophic osteoarthropathy, PHOA) is a rare genetic condition characterised by digital clubbing, pachydermia, hyperhidrosis, cutis verticis gyrata and periostosis. The SLCO2A1 transporter and HPGD enzyme genes play an important role in prostaglandin metabolism, hence loss of function mutations in them causes PHOA. To date, according to the VarSome database 101 and 41 variants have been identified in the SLCO...

ea0065p282 | Neuroendocrinology | SFEBES2019

Onset of radiation-induced hypopituitarism in pituitary adenomas

Seejore Khyatisha , Tudawe Gireesha , Mansoor Tihami , Lynch Julie M , Orme Stephen M , Phillips Nick , Tyagi Atul , Flatley Michael , Loughrey Carmel , Murray Robert D

Introduction: Radiotherapy (RT) can achieve tumour control rates of over 90% in patients with pituitary adenomas. The commonest toxicity of irradiation is hypopituitarism. The exact incidence is variable and requires long-term intermittent testing for deficiency of all hypothalamic−pituitary axes (HPA). The aim of this study is to determine the time to onset of individual hormonal deficiencies and establish a time frame for endocrine testing during follow-up post-RT....