Searchable abstracts of presentations at key conferences in endocrinology

ea0094p240 | Neuroendocrinology and Pituitary | SFEBES2023

Psychiatric side effects of cabergoline treatment of hyperprolactinaemia: risk factors and prevalence of patient counselling and monitoring

Child Louisa , Martin Niamh

Background: There is increasing evidence that dopamine agonists used to treat hyperprolactinaemia may cause psychiatric side effects. Male patients have been identified to be at increased risk. This study aimed to establish the incidence of cabergoline-induced psychiatric side effects, potential risk factors for their development and to determine the prevalence of counselling and monitoring for these side effects.Methods:</strong...

ea0050p043 | Bone and Calcium | SFEBES2017

Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

Li Danyang , Jeffery Louisa , Raza Karim , Hewison Martin

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

ea0050p043 | Bone and Calcium | SFEBES2017

Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

Li Danyang , Jeffery Louisa , Raza Karim , Hewison Martin

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

ea0044p45 | Bone and Calcium | SFEBES2016

Immunomodulation by vitamin D is associated with regulation of microRNAs

Li Danyang , Jeffery Louisa E. , Raza Karim , Hewison Martin

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), acting via the vitamin D receptor (VDR) is a potent regulator of gene expression, with effects on skeletal and extra-skeletal physiology. We have shown that actions of 1,25D on bone-forming osteoblasts also involve regulation of microRNAs (miRNAs) that play a key role in the functional development of these cells. In the current study, we have investigated miRNAs as mediators of innate and adaptive immune responses ...

ea0044ep58 | (1) | SFEBES2016

Endocrine Dysfunction in Diamond Blackfan Anaemia

Talla Maria Rita , McIlwaine Louisa , Panarelli Maurizio , Hughes Kate

Introduction: Diamond Blackfan anaemia (DBA) is a rare disorder of red blood cell aplasia characterized by normocytic or macrocytic anaemia and reticulocytopaenia. Short stature, of multifactorial aetiology, is often present. Some patients are glucocorticoid-responsive, while others remain transfusion-dependent leading to iron overload.Case Report: Asymmetrical growth restriction was present at birth. Aged ten weeks, severe anaemia developed. Bone marrow...

ea0050fut1.3 | Futures 1: Your future in endocrinology and diabetes | SFEBES2017

Clinical academic opportunities in endocrinology

Hunter Louise

A clinical career in Endocrinology is full of research opportunities, be they in basic science, patient cohorts, or at the population level. Research enriches clinical practice, offers new skills, and presents new challenges. Here, partly based on my own experiences as a current Clinical Research Training Fellow, I discuss how to make the most of these opportunities, UK clinical academic training routes, funding options, and where to go for further support and advice....

ea0050fut1.3 | Futures 1: Your future in endocrinology and diabetes | SFEBES2017

Clinical academic opportunities in endocrinology

Hunter Louise

A clinical career in Endocrinology is full of research opportunities, be they in basic science, patient cohorts, or at the population level. Research enriches clinical practice, offers new skills, and presents new challenges. Here, partly based on my own experiences as a current Clinical Research Training Fellow, I discuss how to make the most of these opportunities, UK clinical academic training routes, funding options, and where to go for further support and advice....

ea0047oc20 | Spotlight on Prostate Cancer | Theranostics2016

Evolving evidence of PSMA PET/CT

Emmett Louise

Since its introduction as an imaging agent in humans in 2011, Ga PSMA PET CT has been rapidly embraced clinically for the imaging of prostate cancer both in the setting of biochemical failure and as a staging procedure. The increased sensitivity of the technique in comparison to previously available imaging modalities, and the startling images, have led to a paradigm shift in the treatment of prostate cancer, particularly in the setting of biochemical failure. This talk will g...

ea0046nets5 | What's new in NETs? ENETS guidelines update (new recommendations applied to interactive cases), UK epidemiology and genetics | UKINETS2016

Where NETs fit in with the 100,000 genome project

Izatt Louise

Genomics England with the consent of participants and the support of the public is creating a lasting legacy for patients, the NHS and the UK economy, through the sequencing of 100,000 genomes. 50,000 genomes from cancer, two per patient (tumour and a paired blood sample) and 50,000 from rare disease, three genomes per patient (affected person plus two blood relatives). The main project started sample collection in March 2015, aiming to collect samples by the end of 2017 throu...

ea0038n1.2 | Nurse Session 1: Multiple Endocrine Neoplasia | SFEBES2015

Genetics and multiple endocrine neoplasia

Izatt Louise

Genetic testing plays an increasing role in diagnosing and managing patients with Multiple Endocrine Neoplasia (MEN). Advances in genetic testing technology, combined with a fall in the cost of analysis, provides the opportunity to test more patients as early as possible, to try to confirm or refute whether there is a genetic variant contributing to their endocrine neoplasia. If a MEN syndrome is confirmed genetically, then ongoing management and surveillance can be tailored, ...