Endocrine Abstracts

Most patients with type 1 diabetes, even children and adolescents, have residual insulin secretion at diagnosis. As long as this can be preserved blood glucose fluctuates less, and the risk of acute and late complications decreases. Gradually the autoimmune process will destroy β-cell function unless immune intervention can stop the destructive process.Several different interventions have been tried. The very first intervention with plasmapheresis m...

Objective: Mortality in autoimmune Addison’s disease (AAD) is increased twofold compared to matched populations. Cardiovascular disease (CVD) is the most common cause of death, but little is known of cardiovascular morbidity. Inadequate glucocorticoid replacement has been implicated in the increased risk of CVD, but evidence is lacking. The objective of this study was to examine cardiovascular morbidity and mortality in AAD, and to investigate the effects of glucocorticoi...

Background and aims: Diabetic neuropathy is a common complication of type 1 diabetes. In this study we investigated the importance of long-term metabolic control for the development of diabetic neuropathy in patients with type 1 diabetes diagnosed in childhood.Materials and methods: Longitudinal cohort study. Twenty-five patients (9 women 16 men) were studied three times with neurophysiological measurements and clinical examinations. At baseline the pati...

Background: Hashimoto´s thyroiditis (HT) and Graves´ disease (GD) are known co-aggregate in families, but the magnitude and nature of a shared etiology is unknown. The aim of this study was to estimate the shared genetic influence on these diseases. In addition, we sought to examine if the heritability of HT and GD differs between men and women.Methods: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swe...

The pre-diabetic autoimmune process leading to clinical type 1 diabetes may start already during early infancy. As the incidence of type 1 diabetes is increasing most rapidly among children younger than 5 years in many high and middle income countries (Patterson et al. 2009), there is increasing interest in the impact of early exposures such as diet even before birth.Vitamin D has several effects on the immune system, which could be of potential r...