Searchable abstracts of presentations at key conferences in endocrinology

ea0042oc6 | (1) | Androgens2016

Transgender: biological model for steroid action

Wildt Ludwig , Winkler-Crepaz Katharina , Boettcher Bettina

Transgender patients are treated by down-regulation oft he pituitary gland and the gonads with GnRH- analogues and the opposite male or female sex steroids, followed by gonadectomy. After gonadectomy, the GnRH analogue is discontinued while the treatment with sex steroids (estrogen or testosterone) is continued. This offers the unique possibility to study the effects of sex steroids on bone density, metabolism, and other regulatory systems in the opposite sex. We present data ...

ea0026s22.2 | Non traditional effects of pituitary hormones | ECE2011

Vasopressin and social odour processing in the olfactory system

Ludwig M

Central vasopressin facilitates social recognition and modulates numerous complex social behaviours in mammals, including parental behaviour, aggression, affiliation and pair-bonding. In rodents, social interactions are primarily mediated by the exchange of olfactory information, and there is evidence that vasopressin signalling is important in brain areas where olfactory information is processed. We recently discovered that the rat olfactory bulb (OB)1 and the ante...

ea0025s7.1 | Eat, bond, reproduce – what the hypothalamus dictates | SFEBES2011

Vasopressin and the olfactory system

Ludwig Mike

The neuropeptide vasopressin is now known to be released in the brain where it plays important roles in social behaviours. We have shown that the rat olfactory bulb (OB)1 and the anterior olfactory nucleus (AON)2 contain large populations of interneurones which express and release vasopressin. In the OB, single cell recordings from mitral cells in vivo showed that vasopressin modulates the processing of information by olfactory bulb neurones. Block...

ea0063gh1biog | The Geoffrey Harris Prize Lecture | ECE2019

ESE Geoffrey Harris Prize 2019 – Biography

Günter K Stalla MD, is Professor of Internal Medicine at the Ludwig-Maximilians University, Munich and medical director of Medicover Neuroendocrinology. For almost 30 years, he has been the head of the Department of Internal Medicine and Clinical Neuroendocrinology in the Max Planck Institute of Psychiatry. He finished his residency at the Medical Clinic IV of the Ludwigs-Maximilians University of Munich. He is a...

ea0026p184 | Neuroendocrinology | ECE2011

Vasopressin and vasopressin receptor expression in the rodent retina

Saunders C , Rowe I , Widmer H , Ludwig M

Vasopressin acts through G protein-coupled receptors on the cardiovascular and renal system to induce vasoconstriction and antidiuresis. Vasopressin also has important functions within the CNS influencing cognition, olfaction and a range of complex social interactions and behaviours. In addition, vasopressin has been reported in the mammalian retina and here we investigated the location and expression of vasopressin and vasopressin receptors (V1a, V1b, and V2) in the rat retin...

ea0014p280 | (1) | ECE2007

Non-genomic glucocorticoid effects on insulin secretion

Vila Greisa , Wagner Ludwig , Nabokikh Anastasia , Luger Anton

Glucocorticoids act directly on pancreatic islets suppressing insulin secretion from the beta cells through a genomic mechanism of slow onset. We present here data on immediate actions of dexamethasone on two models of insulin secretion: RINm5F and INS-1 beta cell lines. Under normal glucose concentrations, dexamethasone rapidly (within minutes) decreased insulin secretion about 30%. Under hypoglycaemic conditions (glucose reduced to 50% for 1 hour) dexamethasone increased ins...

ea0011p183 | Clinical practise and governance | ECE2006

Long-acting, intramuscular TestosteronE undecanoatE (TU, Nebido®) in the treatment of female-to-male transgender individuals

Jaobeit JW , Epe M , Hugo U , Ludwig M , Schulte HM

Introduction: Intramuscular Testosterone Undecanoate (TU, Nebido®) has become available in November 2004 in Europe for the treatment of male hypogonadism. Continuous physiological hormone replacement is necessary for transgender patients, both prior to the gender adjustment operation and for the remainder of the individual’s lifetime. The administration of long-acting TU therefore stood to reason as part of cross-gender testosterone therapy for female-to-m...

ea0081ep636 | General Endocrinology | ECE2022

Di-Butyl-Phthalate (DBP) exposure impact on human masculine reproductive hormones. A review of literature

Nita Tiberiu , Paoloni-Giacobino Ariane , Stenz Ludwig , Vernez David , Hopf Nancy

Background: Phthalates are currently used in medical devices, adhesives as plasticizers. Masculine reproductive toxicity is the greatest concern associated with exposure, known as the “phthalate syndrome”. The European Chemicals Agency has recognized di-butyl-phthalate (DBP, CAS 84-74-2) as an endocrine disruptor with deleterious effects on reproductive hormones, with an estimated human intake of 0.84-5.22 μg/kg/day. Effects reported include the disruption of Se...

ea0059p153 | Obesity & metabolism | SFEBES2018

Subcutaneous adipose tissue from patients with Idiopathic Intracranial Hypertension exhibits metabolically distinctive characteristics

Westgate Connar , Markey Keira , Ludwig Christian , Singhal Rishi , Lavery Gareth , Sinclair Alexandra

Idiopathic intracranial hypertension (IIH) is characterised by raised intracranial pressure (ICP) and papilloedema, diagnosed primarily in obese women of reproductive age, with the incidence rising with the global epidemic of obesity. Weight-loss lowers ICP and treats IIH. No mechanism explains the link between obesity and raised ICP. We hypothesise that adipose tissue from IIH patients has a metabolically distinct profile that contributes to raised ICP. Our previous data demo...

ea0032p826 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The role of GLI1 in pituitary tumor formation and pituitary cell survival

Lampichler Katharina , Ferrer Patricio , Vila Greisa , Luger Anton , Knosp Engelbert , Wagner Ludwig , Baumgartner-Parzer Sabina

The transcription factor and proto-oncogene GLI1 is the terminal mediator of the Hedgehog signalling pathway which is involved in developmental processes, stem cell maintenance and cell proliferation. Although the pathway is mainly active during embryogenesis and tissue repair, it is frequently reactivated in several cancer types.Based on these findings we investigated the potential role of GLI1 in the pathogenesis of pituitary adenomas. GLI1 expression ...