Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep1094 | Thyroid cancer | ECE2016

Thyroid nodule ultrasound: which indication for FNA? a prospective study

Riganti Fabrizio , Bonelli Nadia , Rossetto Ruth , Pacchioni Donatella , Viberti Laura , Maccario Mauro , Ghigo Ezio , Garberoglio Roberto

Introduction: Thyroid nodules are discovered by ultrasound (US) in a large percentage of population. In most cases they are benign and asymptomatic. When to perform or not a fine-needle-aspiration (FNA) is still matter of debate. Aim of this study was to evaluate the usefulness of a easy-to-use US classification, based on three US classes.Methods: We prospectively evaluated US features of 1118 thyroid nodules, allocating each nodule in one of three class...

ea0029p70 | Adrenal cortex | ICEECE2012

Primary aldosteronism is very frequent in resistant hypertension and is associated to early renal vascular damage

Benso A. , Lucatello B. , Capello E. , Marafetti L. , Tabaro I. , Caprino M Parasiliti , Ghigo E. , Maccario M.

Background: Data on the prevalence of primary aldosteronism (PA) in subjects with resistant hypertension (inadequate pressure control with three full-dose drugs, including a diuretic) are scanty and it is not known if PA is associated with a more severe vascular damage.Aim: To determine the prevalence of PA in patients with resistant hypertension and define the possible association with early cardiovascular damage.Methods: Seventy ...

ea0022p668 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

IGF1 levels as predictor factor of metabolic derangement in adult patients with severe GH deficiency

Gasco Valentina , Beccuti Guglielmo , Rovere Silvia , Marotta Filippa , Aimaretti Gianluca , Maccario Mauro , Grottoli Silvia , Ghigo Ezio

GH deficiency (GHD) in adults leads to impairment in body composition and function, as well as to deranged lipoprotein and carbohydrate metabolism implying increased cardiovascular morbidity. The morphologic and metabolic alterations in GHD syndrome are more marked in patients with the most severe GHD, even when evaluated by maximal provocative test such as GHRH + arginine. IGF1 synthesis and secretion are function of the GH status but also of major metabolic factors such as i...

ea0011p897 | Thyroid | ECE2006

The GH response to ghrelin in humans is reduced in conditions of hyper- and hypothyroidism

Broglio F , Prodam F , Riganti F , Gramaglia E , Rossetto R , Maccario M , Ghigo E

Both hyper- and hypothyroidism show reduced spontaneous and GHRH-stimulated GH secretion. Although impaired GHRH secretion and activity as well as reduced GH pituitary synthesis have been reported in these pathological conditions, a definitive description of the underlying pathophysiological mechanisms have not been provided yet. Ghrelin elicits a potent GH-releasing effect partially mediated by a functional somatostatin antagonism and a synergic interaction with GHRH. Moreove...

ea0029p73 | Adrenal cortex | ICEECE2012

Idiopathic primary hyperaldosteronism frequently undergoes spontaneous remission: frequence and predictors

Lucatello B. , Benso A. , Tabaro I. , Capello E. , Marafetti L. , Caprino M Parasiliti , Rossato D. , Oleandri S. , Ghigo E. , Maccario M.

Background: Idiopathic primary hyperaldosteronism (IHA) is the subtype of primary aldosteronism (PA) in which lateralization of the mineralocorticoid hypersecretion cannot be demonstrated. Scanty data are available on the clinical history of IHA: a couple of brief reports suggest a remission of aldosterone hypersecretion after years of treatment with mineralocorticoid receptor blocking agents.Aim of this study was to check the persistence/remission of al...

ea0029p1387 | Pituitary Clinical | ICEECE2012

Surveillance study on the prevalence of manifestations, complications and illness associated to acromegaly

Guaraldi F. , Maccario M. , Prencipe N. , Di Giacomo S. , Gasco V. , Berton A. , Mainolfi A. , Ghigo E. , Grottoli S.

Introduction: Acromegaly is a rare disease caused by chronic exposure to excessive levels of GH, usually related to the presence of a pituitary adenoma, and associated to somatic and visceral hypertrophy, metabolic alterations, respiratory and cardiovascular complications, and increased risk of neoplasias.Materials and methods: The prevalence of manifestations, complications and associated illness was evaluated in 137 acromegalic subjects (52 M, 85 F; ag...

ea0029p1447 | Pituitary Clinical | ICEECE2012

Acylated ghrelin as provocative test for the diagnosis of gh deficiency in adults

Gasco V. , Beccuti G. , Baldini C. , Prencipe N. , Guaraldi F. , Di Giacomo S. , Berton A. , Maccario M. , Ghigo E. , Grottoli S.

ITT is the test of reference for the diagnosis of adult GH deficiency (GHD), but also GHRH in combination with arginine (ARG) or GH secretagogues (GHS) are considered equally reliable tests. Testing with GHS alone is, anyway, a potent stimulus exploring the integrity of hypothalamic pathways controlling somatotropic function.We therefore aimed to clarify the diagnostic reliability of testing with ghrelin, the natural GHS.We studied...

ea0081rc7.2 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Development and internal validation of a predictive score for the diagnosis of central adrenal insufficiency when morning cortisol is in the grey zone

Bioletto Fabio , Maria Berton Alessandro , Varaldo Emanuele , Cuboni Daniela , Bona Chiara , Parasiliti Caprino Mirko , Prencipe Nunzia , Ghigo Ezio , Grottoli Silvia , Maccario Mauro , Gasco Valentina

Background: When evaluating a patient for central adrenal insufficiency (CAI), there is a wide range of morning cortisol values for which no final conclusion on hypothalamus-pituitary-adrenal (HPA) axis function can be drawn; in these cases, a stimulation test is required. Aim of this study was to develop an integrated model for the prediction of CAI when morning cortisol is in the grey zone, here defined as 40.0-160.0 μg/l.Methods: Overall, 119 pat...

ea0081rc13.3 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Steroidomic approach for the characterization of patients with non-alcoholic fatty liver disease

Parasiliti Caprino Mirko , Rosso Chiara , Ponzetto Federico , Paolo Caviglia Gian , Lopez Chiara , Armandi Angelo , Maria Saracco Giorgio , Ghigo Ezio , Bugianesi Elisabetta , Maccario Mauro

Introduction: The onset and progression of liver damage in non-alcoholic fatty liver disease (NAFLD) is tightly associated with metabolic derangements. Steroids may affect lipid metabolism but their alterations in the setting of NAFLD remain to be fully explored.Patients and Methods: We analyzed data from 121 patients with biopsy-proven NAFLD and 108 controls (CT). A panel of 26 steroids (including glucocorticoids, mineralocorticoids, androgens, and prog...

ea0081p271 | Adrenal and Cardiovascular Endocrinology | ECE2022

The accuracy of adjusted unconventional indices for the assessment of selectivity and lateralization of adrenal vein sampling in the subtype diagnosis of primary aldosteronism

Bollati Martina , Parasiliti-Caprino Mirko , Bioletto Fabio , Ceccato Filippo , Lopez Chiara , Di Carlo Maria Chiara , Voltan Giacomo , Rossato Denis , Giraudo Giuseppe , Scaroni Carla , Ghigo Ezio , Maccario Mauro

Objective: This study aimed to evaluate the performance of simple and clinical/imaging-corrected unconventional indices in predicting the selectivity of adrenal vein sampling (AVS) and the lateralization of aldosterone hypersecretion in patients with primary aldosteronism (PA).Methods: Data of all consecutive patients with a proven diagnosis of PA who underwent AVS for subtype differentiation in two Italian referral centers were analyzed retrospectively....