Searchable abstracts of presentations at key conferences in endocrinology

ea0011p708 | Reproduction | ECE2006

Androgenic status is influenced by AR polymorphism (CAG repeats number)

Canale D , Caglieresi C , Moschini C , Macchia E , Martino E

Exon 1 of AR gene contains a variable number of CAG triplets, which encode a polyglutamine stretch of variable length in the N-terminal domain of the receptor. Experimental evidence has accumulated in demonstrating that the length of this stretch influences AR transcriptional activity and therefore modulates target organs responsiveness to androgens. Aim of our study was to evaluate CAG repeats length [(CAGr)n] in various conditions hypothetically influenced by AR function. 35...

ea0014p626 | (1) | ECE2007

Androgenicity, androgen receptor polymorphism and pharmacogenetics

Canale Domenico , Moschini Cecilia , Caglieresi Carolina , Moscatelli Agnese , Gavioli Silvia , Macchia Enrico , Martino Enio

Exon 1 of the androgen receptor (AR) gene contains a variable number of CAG triplets, (CAGr)n which encode a polyglutamine stretch of variable length in the N-terminal domain of the receptor. Experimental evidence has accumulated in demonstrating that the length of this stretch influences the transcriptional activity induced by the AR and therefore modulates target organs responsiveness to androgens.The (CAGr)n is inversely associated with the transcript...

ea0011p593 | Neuroendocrinology and behaviour | ECE2006

Differentiation of TSH-oma from thyroid hormone resistance syndrome using thyroid color Doppler sonography

Cosci C , Sardella C , Manetti L , Gasperi M , Tomisti L , Gavioli S , Macchia E , Bogazzi F , Martino E

Thyroid hormone resistance (THR) and pituitary TSH-secreting adenomas (TSHoma) are both characterised by increased serum free thyroid hormone levels and normal TSH concentrations. Differentiation of the two syndromes is a clinical challenge, and relies on the suppression (TRH) or lack of suppression (TSHoma) of TSH-dependent parameters and on the presence of germinal mutations in the thyroid hormone receptor beta 1 gene in patients with THR. Thyroid blood flow, evaluated using...

ea0041oc8.2 | Thyroid - Translational | ECE2016

Selenium modulates apoptosis in thyroid follicular cells: characterization of molecular mechanisms

Cristina Nettore Immacolata , Maione Luigi , Passaro Carmela , Pivonello Claudia , Negri Mariarosaria , Desiderio Silvio , De Nisco Emma , Pivonello Rosario , Ungaro Paola , Portella Giuseppe , Colao Annamaria , Emidio Macchia Paolo

: Inflammation and several oxidative processes are modulated by Selenium (Se) trough the selenoproteins. Se deficiency has been associated with thyroid autoimmune diseases and hypothyroidism, while Se-supplementation reduces antibodies titles and ameliorates ultrasound pattern of the gland.Aim of the current study, is to study the molecular effects of Se-supplementation in thyroid follicular cells (FRTL5).FRTL5 cells have been star...

ea0029oc18.6 | Paediatric Endocrinology | ICEECE2012

The Young Investigator Winner

Nettore I. , Mirra P. , Ferrara A. , Sibilio A. , Kamoi Kay C. , Lorenzoni P. , Werneck L. , Bruck I. , Bequinot F. , Ungaro P. , Fenzi G. , Scola R. , Macchia P.

TTF1/NKX2.1 is a transcription factor expressed in thyroid, lung and brain. Several heterozygous mutations have been described in patients with primary congenital hypothyroidism, respiratory distress and benign hereditary chorea, typical aspects of the ‘thyroid–lung–brain syndrome’.We recently studied a family affected by some of these features, and the direct sequencing of the NKX2.1 gene demonstrated an heterozygous deletion of a cy...

ea0056p387 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

The effect of the dopamine agonist cabergoline on insulin sensitivity in the skeletal muscle: an in vitro study in a mouse cell model demonstrating mediation by serotoninergic receptors

Negri Mariarosaria , Pivonello Claudia , Gennaro Gilda Di , Angelis Cristina de , Simeoli Chiara , Iacuaniello Davide , Nettore Immacolata Cristina , Macchia Paolo Emidio , Muscogiuri Giovanna , Colao Annamaria , Pivonello Rosario

Insulin resistance (IR), characterized by an impairment of target tissues to insulin responsiveness, is the core defect preceding diabetes. Preclinical and clinical data have suggested a role for the dopaminergic system in glucose homeostasis control. The aim of the current study was to investigate the role of the dopamine agonist cabergoline (CAB), displaying high affinity for dopamine type 2 (DR2) receptor and low affinity for serotonin receptors (5-HTRs), in the regulation ...