Searchable abstracts of presentations at key conferences in endocrinology

ea0011p397 | Diabetes, metabolism and cardiovascular | ECE2006

Dietary potassium driven responses in the renal WNK kinase pathway in vivo

O’Reilly M , Marshall E , MacGillvray T , Mittal M , Kenyon CJ , Brown RW

WNK1 (With-No-K, lysine) and WNK4 are serine/threonine kinases, mutated in Gordon syndrome (Pseudohypoaldosteronism Type II), a dominant, hypertensive, hyperkalaemic disorder; implicating this novel WNK pathway in normal regulation of blood pressure (BP) and electrolyte balance. Previous Xenopus oocyte work implicates WNK4 in regulation of K+ secretion via ROMK (renal outer medullary K+ channel) and Cl- transport pathways both paracellularly via tight junctions (claudin...