Endocrine Abstracts

Introduction: Neurofibromatosis type 1 (NF1), also known as von Recklinghausen’s disease, is the most common type of NF and one of the most frequent human genetic diseases. Gynaecomastia due to pseudoangiomatous stromal hyperplasia (PASH) in patients with NF1 is quite a rare complication but still it should be differentiated from gynecomastia caused by other conditions.Clinical case: A 30-year-old man, previously diagnosed with NF1 at the age of 19,...

Aim of the study: To analyze the dynamics and levels of incretins and neuropeptides secretion in patients with CD and acromegaly and therefore to specify the pathogenesis of carbohydrate metabolism disturbances.Methods: Forty-two patients with Cushing disease and acromegaly were included into the study. All patients were newly diagnosed with Cushing disease and acromegaly. Oral glucose tolerance test (OGTT), during which glucose, glucagon, glucagon like ...

Objective: To investigate osteoporosis features in elder patients in Moscow populationMaterials and Methods: It was a retrospective study, during which we analyzed the data of 192 outpatients admitted to our Centre. In the focus of our attention was patients’ past medical history and T-criteria values assessed by DEXA-scan. The statistical analysis was performed using Prism 8 Version 8.0.1 (145). Statistically significant were differences with P...

Aim of the study: To investigate osteoporosis features in elder patients in Moscow population.Materials and Methods: It was a retrospective study, during which we analyzed the data of 192 outpatients (183 women and 9 men) admitted to Gerontology Research and Clinical Centre in 2018. In the focus of our attention was patients’ past medical history, such as any antiosteoporotic treatment received, vitamin D and Ca supplementations, any fractures in pr...

The relevance of carbohydrate metabolism studying in patients with Cushing disease (CD) and acromegaly can be explained by frequent occurrence of glucose metabolism disturbances on the one hand, and difficulties in glucose-lowering therapy in these patients on the other. The effectiveness of hyperglycaemia treatment may be reduced due to difficulties in remission/cure of the underlying disease, as well as to the use of specific drug-therapy, leading to hyperglycaemia. There is...

Introduction: Acromegaly is a chronic, debilitating disorder caused by excessive growth hormone (GH) production predominantly due to a benign pituitary adenoma. The overall annual incidence of acromegaly is approximately 3.3 cases/million, with a prevalence of 58–130 cases/million people. Early carbohydrate metabolism disorders (ECMDs) are frequently associated with acromegaly. ECMDs – defined as IFG, IGT or their combination – its prevalence in patients with ac...

Aim of the study: to assess the interaction between TSH and the most common geriatric syndromes in the cohort of centenarians Materials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. We analyzed the interactions between TSH, m...

Aim of the study: To assess the most important metabolic factors in centenarians and their impact on mortality and prognosisMaterials and methods: Itwasalongitudinalstudy, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and MOCA scores. We also analyzed levels of HbA1c, cholesterol, LDL, H...

IntroductionMetformin and vildagliptin are the medications amongst first-line treatment options in type 2 diabetes patients. Few recent studies have explained positive pleotropic effects of metformin therapy by telomerase activation and telomeres length in leukocytes preservation. Knowing the primary role of insulin-signalling pathway in insulin resistance development and physiology of ageing, it is possible to suggest, that one of the protective mechani...

Aim of the study: To assess vitamin D levels in centenarians and its interaction with the most common geriatric syndromesMaterials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. QoL questionnaires were used as well. In all pat...