Searchable abstracts of presentations at key conferences in endocrinology

ea0009p203 | Clinical | BES2005

An incidental phaeochromocytoma

Tahrani A , Macleod A

48 year-old woman was referred to the endocrine clinic by the respiratory team for management of an incidental 2cm right adrenal mass found on chest/upper abdomen computed tomography (CT) as part of investigations for recurrent chest infections. On review, she described attacks of ' doom and gloom', flushing and palpitations with a rate of 140 beats per minute. The attacks were sporadic and occurred for some years. Blood pressure in the endocrine clinic was 210/110. Urea and e...

ea0009p190 | Clinical | BES2005

A case of insulin sensitivity

Tahrani A , Macleod A , West T

A 32-year-old woman was referred, at 12 weeks in her second pregnancy, to the antenatal diabetic clinic for control of Type 1 diabetes. HbA1c was 6.5% (4.5-6.2%DCCT).At 32 weeks gestation she was admitted with premature labour. Treatment with betamethasone resulted in hyperglycaemia. Four days later she was admitted with a suspected subarachnoid haemorrhage. Brain CT was normal. She declined lumbar puncture. Over the next 2 days she developed recurrent h...

ea0007p231 | Thyroid | BES2004

Pretibial myxoedema as the first manifestation of Graves disease

Watt A , Vaidya B , Macleod K

Pretibial myxoedema (thyroid-associated dermopathy), an extrathyroidal manifestation of Graves disease, is a localized thickening of the skin due to accumulation of acid mucopolysacharides (glycosaminoglycans). Almost invariably, pretibial myxoedema occurs in the presence of ophthalmopathy.We report the case of a 57-year-old man of North African origin, who presented with pretibial myxoedema as the first manifestation of Graves disease. He was admitted w...

ea0081p351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glucokinase (GCK) diabetes

Abouzaid Mona , MacLeod Jean , Aggarwal Naveen

Background: Glucokinase (GCK) is a gene which plays an important role in recognising how high the blood glucose is in the body. It acts as the glucose sensor for the pancreas. Changes in the GCK gene can lead to increases in blood glucose and affected people may be diagnosed with diabetes although this rise in blood glucose is mild and does not need treatment. Glucokinase diabetes is one of familial diabetes types that called MODY (maturity onset diabetes of the young). We rep...

ea0037ep1332 | Clinical Cases–Thyroid/Other | ECE2015

Leg oedema: first sign of an ischemic leg which precipitated hyperosmolor hyperglycemic state in a newly diagnosed type 2 diabetes patient

Kalidindi Sushuma , Moulik Probal , Macleod Andrew

Patients with diabetes are prone to peripheral vascular disease. We present the case of an 81 year old female, current smoker who presented to her general practitioner with a 3 day history of ankle oedema for which she received furosemide. She had a background of right above knee amputation due to peripheral vascular disease and essential thrombocythaemia. Five days after commencing furosemide, she developed increased lethargy and confusion. On arrival to hospital, her venous ...

ea0031p118 | Clinical practice/governance and case reports | SFEBES2013

Bilateral adrenal calcification caused by a previous Streptococus mitis septicaemia

Ahmed Mohamed , Moulik Probal , Macleod Andrew

This 23 years old man was noted incidentally to have bilateral adrenal calcification on CT scan of his abdomen for chronic abdominal pain. He had normal growth and milestones with no neonatal events. Aged 10 years he was admitted briefly to a high dependency unit with circulatory shock and hyperthermia, with isolation of Streptococcus mitis from blood culture. One year later he was noted to have bilateral adrenal calcification on abdominal XR, and a short Synacthen (250 μ...

ea0028p76 | Clinical practice/governance and case reports | SFEBES2012

Letrozole induced Hypertestosteronism

Krishnasamy Senthilkumar , Macleod Andrew , Moulik Probal

Background: Letrozole is a potent aromatase inhibitor licensed for use in women with breast cancer. It is also used by body builders for reduction of gynecomastia when taking anabolic steroids. Supply for this unlicensed use is readily available through internet. Testosterone production is regulated by negative feedback of estrogen on the pituitary. The use of letrozole can therefore cause supraphysiological levels of testosterone in men. We present such a case.<p class="a...

ea0028p82 | Clinical practice/governance and case reports | SFEBES2012

Ectopic parathyroid cyst presenting with parathyroid crisis

Krishnasamy Senthilkumar , Moulik Probal , Macleod Andrew

Background: Primary Hyperparathyroidism is mainly produced by an adenoma and it is mostly a benign condition. Most of the patients are asymptomatic. We present a case of ectopic parathyroid cyst presenting with this condition.Case: A 76 yr female presented with new onset confusion, abdominal pain, vomiting, diarrhoea and dehydration. She was currently being treated for a urinary tract infection. Investigations showed acute kidney injury with creatinine 3...

ea0028p98 | Clinical practice/governance and case reports | SFEBES2012

Audit of detection and management of adrenal incidentalomas at a district general hospital

Krishnasamy Senthilkumar , Moulik Probal , Macleod Andrew

Objectives: Increasing use of scanning has led to a significant increase in detection of adrenal incidentalomas. The American Association of Clinical Endocrinologists and American Association of Endocrine Surgeons have issued guidelines for evaluation of adrenal incidentalomas in 2009. We audited our current practice at Royal Shrewsbury Hospital against the 2009 guidelines.Method: Retrospective audit of patients found to have adrenal masses on imaging st...

ea0028p332 | Steroids | SFEBES2012

Bilateral adrenal enlargement with Hypoadrenalism

Krishnasamy Senthilkumar , Moulik Probal , Macleod Andrew

Background: Primary hypoadrenalism with bilateral adrenal enlargement is a relatively rare condition. We present four such patients. Case 1: 60 year old male presented with malaise, weight loss and hyponatremia. Short synacthen test was abnormal and ACTH was raised (309 ng/L). CT adrenals showed bilateral adrenal enlargement with uniform texture and low attenuation with no change in repeat CT. FNAC of adrenal gland showed infarcts. Further tests confirmed antiphospholipid anti...