Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc4.8 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Impaired insulin secretion without changes in insulin sensitivity explains hyperglycemia in patients with acromegaly treated by pasireotide LAR

Wolf Peter , Dormoy Alexandre , Maione Luigi , Salenave Sylvie , Young Jacques , Kamenicky Peter , Chanson Philippe

Background: Pasireotide is a second line treatment for acromegaly. Besides the growth hormone (GH) lowering efficacy, clinical use is limited by side effects on glycemic control. The aim of this study was to evaluate longitudinal changes in beta-cell function and insulin sensitivity induced by pasireotide therapy in patients with acromegaly.Methods: We performed a retrospective study in 33 patients. Efficacy (GH and IGF-I concentrations; tumor size) and ...

ea0063gp145 | Interdisciplinary Endocrinology 1 | ECE2019

Final (FH) and target height (TH) in male and female patients with congenital hypogonadotropic hypogonadism (CHH)/Kallmann syndrome (KS): a monocentric study of 216 patients

Maione Luigi , Pala Giovanna , Trabado Severine , Papadakis Georgios , Maghnie Mohamad , Bouvattier Claire , Young Jacques

Context: CHH/KS is a major cause of pubertal and bone maturation delay due to sex steroids deficiency. FH and TH have not been evaluated in large series of CHH/KS patients. Analysis of auxometric measures in patientsÂ’ siblings has never been performed.Patients and methods: We selected 216 (164/52 men/women; 112/104 KS/normosmic CHH) with available auxometric measures. Sibling stature was available in a subgroup of 162 patients. Difference between th...

ea0063p821 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The malignant potential of oncocytic adrenal tumours should not be underestimated

Fontaine Benedicte , Flaus-Furmaniuk Anna , Jelloul Emna , Mosbach Helena , Maione Luigi , Chanson Philippe , Debussche Xavier

Background: Oncocytic neoplasms are rare adrenal tumours usually considered as benign and non-functional. Conversely, in recent large nationwide study from COMETE network over 50% of the oncocytic adrenocortical tumours were diagnosed as carcinoma according to Lin Weiss-Bisceglia-score. However, until now only 11 cases of metastatic oncocytoma were reported in English literature.Case report: A 54-year-old man with history of abdominal pain and weight los...

ea0032oc5.6 | Reproduction | ECE2013

INSL3 in 268 male patients with congenital hypogonadotropic hypogonadism (CHH): effects of different modalities of hormonal treatment

Trabado Severine , Maione Luigi , Sarfati Julie , Salenave Sylvie , Chanson Philippe , Brailly-Tabard Sylvie , Young Jacques

Context: Insulin-like peptide three (INSL3) is a testicular hormone, secreted by Leydig cells, during fetal life, in newborns, and after puberty. These 3 phases of testicular activation are impaired in CHH.Objective: To evaluate in a single center circulating INSL3 in a significant series of men with CHH in order to asses the consequences of pre- and postnatal gonadotropin deficiency, to specify the INSL3 regulation by gonadotropins and to evaluate the p...

ea0029p1080 | Neuroendocrinology | ICEECE2012

CT Scan of the anterior skull base in Kallmann syndrome reveals specific ethmoid abnormalities

Maione L. , Benadjaoud S. , Ducreux D. , Sinisi A. , Chanson P. , Benoudiba F. , Young J.

Context: Kallmann syndrome (KS) is a developmental disease associating congenital hypogonadotropic hypogonadism (CHH) and sense of smell impairment owing to olfactory structures (OS) aplasia/hypoplasia. Although rhinencephalic MRI allows to detect specific KS OS abnormalities useful to discriminate KS from normosmic CHH (nCHH), this technique is not efficient enough to study anterior skull bone structures.Objectives: To search for specific anterior skull...

ea0020p185 | Endocrine tumours and neoplasia | ECE2009

Estradiol influences somatostatin receptor expression and potentiates the effects of SOM230 on prostate cells

Rossi Valentina , Bellastella Giuseppe , Visconti Daniela , Abbondanza Ciro , Maione Luigi , Bellastella Antonio , Agostino Sinisi Antonio

Somatostatin (SS) receptors (SSR) expression may be modulated by estrogens in breast cancer cells. Aim of this study was to evaluate the effects of estradiol (E2) on SSR levels in prostate epithelial cells (PEC).Methods: We investigated the effects of E2 and SS-analogue SOM230 combined treatment on two PEC lines: EPN that expresses both ERalfa and beta and CPEC, showing no ERalfa and very low ERbeta expression. Cells starved in red ...

ea0011p551 | Endocrine tumours and neoplasia | ECE2006

In vitro effects of som230 on primary cultured pheochromocytoma cells

Pasquali D , Conzo G , Rossi V , Bellastella G , Maione L , Bellastella A , Sinisi AA

The stable somatostatin analog octreotide has been successfully used for imaging and treatment of a variety of human tumors. Octreotide treatment has been reported of limited value in pheochromocytoma (PHEO). PHEOs often express more than one somatostatin receptor, and it is uncertain by which receptor subtype the functional responses of octreotide are mediated. A recent study showed by immunohistochemical staining that vast majority of tumors (90%) were positive for sst(3), i...

ea0090p572 | Calcium and Bone | ECE2023

Similarities and differences between thyroid and parathyroid nodules on ultrasound: the PARATH-US study

Yazgi Dolly , Richa Carine , Salenave Sylvie , Kamenicky Peter , Bourouina Amel , Clavier Lorraine , Young Jacques , Chanson Philippe , Maione Luigi

Context: Cervical ultrasound is a frequently used and an accessible operator-dependent tool, which contributes to the characterization of thyroid nodules and to the preoperative localization of pathological parathyroid glands. However, thyroid nodules may be confused with parathyroid lesions. There is no study directly comparing thyroid and parathyroid nodules on ultrasound.Objectives: 1) To describe the ultrasonographic characteristics of parathyroid le...

ea0090p465 | Reproductive and Developmental Endocrinology | ECE2023

Sexual dimorphism in the LH responses to kisspeptin and senktide administration in prepubertal mice

Maione Luigi , Naule Lydie , Yang Ling Li Chloe , Magnuson Melissa , Young Jacques , Stephanie Carroll Rona , Kaiser Ursula

Introduction: The hypothalamic-pituitary-gonadal (HPG) axis is regulated by pulsatile GnRH secretion and its action on the anterior pituitary, leading to the synthesis and secretion of LH and FSH. KNDy neurons, expressing kisspeptin, neurokinin B and dynorphin A, are the GnRH/lH pulse generator and are key regulators of puberty and fertility. The HPG axis is active during prenatal and early postnatal life in humans and rodents, but then remains quiescent until puberty in both ...

ea0063p308 | Reproductive Endocrinology 1 | ECE2019

Reproductive phenotype in 265 men with congenital hypogonadotropic hypogonadism and 531 men with acquired hypogonadotropic hypogonadism: a monocentric comparative study

Maione Luigi , Sarfati Julie , Bernard Valerie , Gonfroy Celine , Jublanc Christel , Salenave Sylvie , Trabado Severine , Chanson Philippe , Young Jacques

Context: Hypogonadotropic hypogonadism (HH), defined by LH and FSH deficiencies, lead to impairment in testicular growth, testicular hormonal secretions and spermatogenesis. HH can have a prenatal (congenital HH, CHH) or post-natal (acquired HH, HHA) onset. Direct comparison of reproductive phenotypes (RP) between CHH and AHH has not been systematically performed in large series representative of these two populations.Patients and methods: 60 normal men,...