Searchable abstracts of presentations at key conferences in endocrinology

ea0029p704 | Diabetes | ICEECE2012

Pathway Integration of Pro-Inflammatory Cytokines, 12-Lipoxygenase and NADPH Oxidase in Beta Cell Dysfunction; Protection by Novel Selective 12-Lipoxygenase Inhibitors.

Taylor-Fishwick D. , Weaver J. , Ganesha B. , Holman T. , Jadhav A. , Maloney D. , Nadler J. , Simeonov A.

In this study we explore and integrate a pathway for loss of functional beta cell mass in diabetes. Inflammatory cytokines induce human islet dysfunction, elevate expression of 12-lipoxygenase, increase cellular reactive species and induce NADPH oxidase. These pathways are elevated in islets from diabetic donors.NADPH oxidase-1 (NOX-1) is significantly induced in either human donor islets, primary mouse islets or homogeneous beta cell lines following sti...

ea0024p14 | (1) | BSPED2010

Evaluation of terminology used to describe disorders of sex development

Knight E , Malone P , Savage A , Brown J , Davies J

Objective: The terminology used to describe abnormalities of sex determination and sex differentiation was revised in 2006. It was anticipated that new terms, such as Ā“disorder of sex developmentĀ” (DSD), would improve communication between health professionals, aid parental understanding and be acceptable to affected individuals. The purpose of this study was to evaluate whether the new terminology has been an improvement compared to previous nomenclature.<p clas...